{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:02:06Z","timestamp":1791669726009,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Limited investigation of factors potentially contributing to treatment choice in early\u2010stage glottic carcinoma (EGC) has been performed with large\u2010scale data. The National Cancer Database (NCDB) represents &gt;72% of all new cancer cases in the United States. We hypothesized that NCDB variables may lend insight into treatment decisions between surgery and radiation for EGC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The NCDB was queried for all cases of T<jats:sub>1\u20102<\/jats:sub>\u00a0N<jats:sub>0<\/jats:sub>\u00a0M<jats:sub>0<\/jats:sub> glottic carcinoma from 2004 to 2016. We used multivariable logistic regression analysis to examine factors associated with first\u2010line treatment modality:\u00a0radiation therapy (RT) versus surgery. All reported odds ratios (OR) were adjusted for age, gender, race, insurance, residence in a metropolitan area, region, and facility volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>34,991 EGC patients received treatment: 6,687 (19%) surgery; 20,289 (58%) RT; and 8,015 (23%) surgery and RT. OR for receiving RT (vs. surgery alone) were\u2009&gt;2 for: more advanced T stage cancers (OR 2.5 [95%CI: 2.3, 2.7]), treatment at non\u2010academic facilities (OR 2.8, [95%CI: 2.6, 3.0]), and shorter travel distances to treatment centers (OR 2.2, [95%CI: 2.0, 2.4]). Surgery was more likely with treatment in the western US, higher income, private insurance, living in a metropolitan (vs. non\u2010metropolitan) area, female gender, older age, and low facility volume. Hispanic ethnicity, education level, and race were not associated with treatment type in the multivariable model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most patients in the NCDB receive first\u2010line treatment with radiation for EGC, and this decision is associated with various tumor, patient, and treatment facility characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 133:901\u2013907, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30305","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T18:43:32Z","timestamp":1658256212000},"page":"901-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>Early\u2010Stage<\/scp> Glottic Carcinoma in the United States: Demographics and Treatment Choice"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-3442","authenticated-orcid":false,"given":"Aaron D.","family":"Friedman","sequence":"first","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2010Head and Neck Surgery University of Cincinnati Medical Center  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Gengler","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2010Head and Neck Surgery University of Cincinnati Medical Center  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekibib","family":"Altaye","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4300-5146","authenticated-orcid":false,"given":"Meredith E.","family":"Tabangin","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"American College of Surgeons.National Cancer Database.https:\/\/www.facs.org\/quality-programs\/cancer\/ncdb. 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