{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:08:32Z","timestamp":1790287712924,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical patterns and disease evolution of laryngopharyngeal reflux (LPR) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with LPR diagnosed by hypopharyngeal\u2010esophageal impedance\u2010pH monitoring were prospectively followed in three medical centers. Symptoms and findings were assessed with reflux symptom score (RSS) and reflux sign assessment (RSA). Patients were treated with 3\u2010to 9\u2010month diet and combination of proton pump inhibitors, alginate or magaldrate. Patients were followed for 3\u2009years to determine the clinical evolution of symptoms over time. LPR that did not recur was defined as acute. Recurrent LPR consisted of reflux with one or several recurrences yearly despite successful treatment. Chronic LPR was reflux with a chronic course of symptoms. Predictive indicators of clinical evolution were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred forty patients and 82 healthy individuals completed the evaluations. Among patients, 41 (29.3%), 57 (40.7%), and 42 (30.0%) had acute, recurrent, or chronic LPR respectively. Baseline quality of life\u2010RSS (QoL\u2010RSS) and RSS total scores were significantly higher in chronic LPR patients. The post\u2010treatment decrease of QoL\u2010RSS and RSS of acute LPR patients were significantly faster as compared to recurrent and chronic patients. QoL\u2010RSS &gt;5 reported adequate sensitivity (94.2) and specificity (75.3). QoL\u2010RSS thresholds defined acute (QoL\u2010RSS\u00a0=\u00a06\u201325), recurrent (QoL\u2010RSS\u00a0=\u00a026\u201338), and chronic (QoL\u2010RSS\u2009&gt;\u200938) LPR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Baseline QoL\u2010RSS may predict the clinical course of LPR patients: acute, recurrent, or chronic. A novel classification system that groups patients according to the longevity, severity, and therapeutic response of symptoms was proposed: the International Federation of Otorhinolaryngological Societies Classification of LPR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      3\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 133:1073\u20131080, 2023\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.30322","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T04:44:35Z","timestamp":1659501875000},"page":"1073-1080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Acute, Recurrent, and Chronic Laryngopharyngeal Reflux: The\n                    <scp>IFOS<\/scp>\n                    Classification"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"J\u00e9r\u00f4me R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Elsan Hospital  Paris France"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Foch Hospital, School of Medicine, UFR Simone Veil, Universit\u00e9 Versailles Saint\u2010Quentin\u2010en\u2010Yvelines (Paris Saclay University)  Paris France"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons)  Mons Belgium"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery CHU Saint\u2010Pierre (CHU de Bruxelles)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-6145","authenticated-orcid":false,"given":"Quentin","family":"Lisan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Foch Hospital, School of Medicine, UFR Simone Veil, Universit\u00e9 Versailles Saint\u2010Quentin\u2010en\u2010Yvelines (Paris Saclay University)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia A.","family":"Eckley","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Otorrinolaringologia Fleury Medicina e Sa\u00fade Laborat\u00f3rios de Diagn\u00f3stico  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-3568","authenticated-orcid":false,"given":"Abdul\u2010Latif","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-5207","authenticated-orcid":false,"given":"Young\u2010Gyu","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery School of Medicine, Kyung Hee University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Hans","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Foch Hospital, School of Medicine, UFR Simone Veil, Universit\u00e9 Versailles Saint\u2010Quentin\u2010en\u2010Yvelines (Paris Saclay University)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons)  Mons Belgium"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery CHU Saint\u2010Pierre (CHU de Bruxelles)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-0545","authenticated-orcid":false,"given":"Lee M.","family":"Akst","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins Hospital, Johns Hopkins School of Medicine  Baltimore Maryland U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-2482","authenticated-orcid":false,"given":"Thomas L.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Harvard Medical School  Boston Massachusetts U.S.A."},{"name":"Division of Otolaryngology, Department of Surgery Brigham and Women's Hospital  Boston 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