{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:12:26Z","timestamp":1791828746223,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the oncological outcomes of salvage transoral laser microsurgery (TLM) in the treatment of patients suffering from recurrent laryngeal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed\/MEDLINE, Cochrane Library, and Scopus databases were searched. English language, original studies investigating oncological outcomes of TLM in adult patients with recurrent laryngeal cancer were included. Data were pooled using a distribution\u2010free approach for estimating summary local control (LC), disease\u2010specific survival (DSS), and overall survival (OS) curves with random effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred and thirty\u2010five patients underwent salvage TLM after primary (chemo)radiotherapy. The mean follow\u2010up time was 60.8\u2009months (95% CI: 32.7\u201388.9). Estimated pooled LC rates (95% CI) at 1, 3 and 5\u2009years were 74.2% (61.7\u201389.4), 53.9% (38.5\u201375.3), and 39.1% (25.2\u201360.8). Estimated pooled DSS rates (95% CI) at 1, 3 and 5\u2009years were 88.4% (82.0\u201395.3), 67.8% (50.9\u201390.3), and 58.9% (42.7\u201381.1). Two hundred and seventy\u2010one patients underwent TLM after primary laser treatment. The mean follow\u2010up time was 70.9\u2009months (95% CI: 36.9\u2013104.9). Estimated pooled LC rates (95% CI) at 1, 3 and 5\u2009years were 72.2% (64.7\u201380.6), 53.2% (42.2\u201366.9), and 40.4% (29.6\u201355.2). Estimated pooled DSS rates (95% CI) at 1, 3 and 5\u2009years were 92.1% (85.5\u201399.1), 77.0% (64.4\u201392.0), and 67.1% (51.6\u201387.3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TLM is a valuable treatment option for the management of locally recurrent laryngeal carcinoma if performed by experienced surgeons and following rigorous patients' selection criteria. Further studies should be conducted to define stage\u2010based clinical guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      NA\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 133:1425\u20131433, 2023\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.30332","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T07:24:39Z","timestamp":1659597879000},"page":"1425-1433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Transoral Laser Microsurgery in Recurrent Laryngeal Cancer: A Systematic Review and 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