{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T08:47:46Z","timestamp":1769935666992,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To elucidate potential tissue coverage of side\u2010firing optical fibers in office\u2010based endoscopic laser treatment of larynx, as well as to demonstrate their enhanced ability to address challenging anatomic areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a comparative study of four different fiber designs: a traditional forward\u2010facing fiber, and three side\u2010firing fibers that emit light at an angle of 45\u00b0, 70\u00b0, and 90\u00b0, respectively. The study was conducted in simulation, using eight three\u2010dimensional models of the human larynx generated from microtomography x\u2010ray scans. A computer program simulated the insertion of the endoscope into the larynx, and the M\u00f6ller\u2013Trumbore algorithm was used to simulate the application of laser light.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Side\u2010firing laser fibers increased potential tissue coverage by a mean of 50.2 (standard deviation [SD] 25.8), 73.8 (SD 41.3), and 84.0 (SD 47.6) percent for angles of 45\u00b0, 70\u00b0, and 90\u00b0, respectively, compared to forward\u2010facing fibers. Angled fibers provided access to areas of the larynx considered difficult to address by traditional methods, including the infraglottis, laryngeal ventricle, and right vocal fold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Simulation results suggest that side\u2010firing optical fibers have the potential to enhance anatomical access during in\u2010office endoscopic laser procedures in the larynx. Further research is needed to better understand the benefits and any potential risks or contraindications of side\u2010firing optical fibers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 133:1205\u20131210, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30363","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T12:21:39Z","timestamp":1662380499000},"page":"1205-1210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Benefits of Side\u2010Firing Optical Fibers in Endoscopic Laser Treatment of the Larynx"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-9238","authenticated-orcid":false,"given":"Elliana Kirsh","family":"DeVore","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School  Boston Massachusetts 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