{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:40:35Z","timestamp":1790718035131,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002489"],"award-info":[{"award-number":["UL1TR002489"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess long\u2010term binaural hearing abilities for cochlear implant (CI) users with unilateral hearing loss (UHL) or asymmetric hearing loss (AHL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective, longitudinal, repeated measures study was completed at a tertiary referral center evaluating adults with UHL or AHL undergoing cochlear implantation. Binaural hearing abilities were assessed with masked speech recognition tasks using AzBio sentences in a 10\u2010talker masker. Performance was evaluated as the ability to benefit from spatial release from masking (SRM). SRM was calculated as the difference in scores when the masker was presented toward the CI\u2010ear (SRM\n                      <jats:sub>ci<\/jats:sub>\n                      ) or the contralateral ear (SRM\n                      <jats:sub>contra<\/jats:sub>\n                      ) relative to the co\u2010located condition (0\u00b0). Assessments were completed pre\u2010operatively and at annual intervals out to 5\u2009years post\u2010activation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty UHL and 19 AHL participants were included in the study. Linear Mixed Models showed significant main effects of interval and group for SRM\n                      <jats:sub>contra<\/jats:sub>\n                      . There was a significant interaction between interval and group, with UHL participants reaching asymptotic performance early and AHL participants demonstrating continued growth in binaural abilities to 5\u2009years post\u2010activation. The improvement in SRM showed a significant positive correlation with contralateral unaided hearing thresholds (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.050) as well as age at implantation (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.031).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CI recipients with UHL and AHL showed improved SRM with long\u2010term device use. The time course of improvement varied by cohort, with the UHL cohort reaching asymptotic performance early and the AHL cohort continuing to improve beyond 1\u2009year. Differences between cohorts could be driven by differences in age at implantation as well as contralateral unaided hearing thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      3\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 133:1480\u20131485, 2023\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.30368","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T06:24:18Z","timestamp":1661754258000},"page":"1480-1485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010Term Binaural Hearing Improvements for Cochlear Implant Users with Asymmetric Hearing Loss"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5426-4883","authenticated-orcid":false,"given":"Nicholas J.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-8702","authenticated-orcid":false,"given":"Kevin D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Buss","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith A.","family":"Rooth","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill North Carolina U.S.A."},{"name":"Division of Speech and Hearing Sciences, Department of Allied Health Sciences University of North Carolina at Chapel Hill  Chapel Hill North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-283X","authenticated-orcid":false,"given":"Margaret T.","family":"Dillon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of North Carolina at Chapel Hill  Chapel Hill North Carolina U.S.A."},{"name":"Division of Speech and Hearing Sciences, Department of Allied Health Sciences University of North Carolina at Chapel Hill  Chapel Hill North Carolina U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000380"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2011\/10-0205)"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.395906"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.08.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992020600782626"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.2945710"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1354984"},{"key":"e_1_2_7_9_1","unstructured":"U.S. Food and Drug Administration Center for Devices and Radiological Health.MED\u2010EL Cochlear Implant System for Expanding the Indications to Include Single\u2010Sided Deafness and Asymmetric Hearing Loss 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