{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:12:35Z","timestamp":1782267155746,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate speech outcomes and facial nerve stimulation (FNS) rates in patients with far advanced otosclerosis (FAO) after cochlear implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was performed using standardized methodology of Medline, EMBASE, PubMed, Cochrane, and Web of Science databases. Studies were included if adults with FAO underwent cochlear implantation. Exclusion criteria included concurrent otologic history (e.g., Meniere's disease, superior canal dehiscence), non\u2010English\u2010speaking implant users, case reports, abstracts, and letters\/commentaries. Bias was assessed using the Newcastle\u2010Ottawa Scale for cohort studies and the National Institute of Health Scale for case series. The primary outcome measure was speech discrimination and the secondary outcomes were rates of partial insertion and FNS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven studies evaluated cochlear implantation in FAO. Due to the heterogeneity of testing methods, statistical pooling of speech discrimination was not feasible, but qualitative synthesis indicated a positive effect of implantation. Pooled rates of FNS were 18% (95% confidence interval, CI 12%\u201327%) and the rate of partial insertion was 10% (95% CI 7%\u201315%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cochlear implantation in FAO demonstrates significant gains in speech discrimination scores with higher rates of FNS and partial insertion. <jats:italic>Laryngoscope<\/jats:italic>, 133:1288\u20131296, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30386","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T19:54:16Z","timestamp":1662753256000},"page":"1288-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cochlear Implantation in Far Advanced Otosclerosis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-161X","authenticated-orcid":false,"given":"Mickey","family":"Kondo","sequence":"first","affiliation":[{"name":"Division of Otolaryngology Head and Neck Surgery Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik","family":"Vasan","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Head and Neck Surgery Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas Emmanuel","family":"Jufas","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Head and Neck Surgery Royal North Shore Hospital  Sydney New South Wales Australia"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Faculty of Medicine and Health Sciences Macquarie University  Sydney New South Wales Australia"},{"name":"Discipline of Surgery, Sydney Medical School University of Sydney  Sydney New South Wales Australia"},{"name":"Kolling Deafness Research Centre, Royal North Shore Hospital Macquarie University and University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Head and Neck Surgery Royal North Shore Hospital  Sydney New South Wales Australia"},{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Faculty of Medicine and Health Sciences Macquarie University  Sydney New South Wales Australia"},{"name":"Discipline of Surgery, Sydney Medical School University of Sydney  Sydney New South Wales Australia"},{"name":"Kolling Deafness Research Centre, Royal North Shore Hospital Macquarie University and University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"726","volume-title":"Schuknecht's Pathology of the Ear","author":"Schuknecht HF","year":"2010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200407000-00010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420921420"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946107000411"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000692"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600987768"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)32577-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860030075012"},{"key":"e_1_2_6_10_1","volume-title":"Surgery for Cochlear and Other Auditory Implants","author":"Sanna M","year":"2016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106773"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31819d34c9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2014.03.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2012.05.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200411000-00014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816655310"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2017.05.011"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.5152\/tao.2020.4600"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000637"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001552"},{"key":"e_1_2_6_21_1","unstructured":"OCEBM Levels of Evidence Working Group.The Oxford 2020 Levels of evidence: Oxford Centre for evidence\u2010based medicine. 2020. 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