{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:41:22Z","timestamp":1785847282368,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Vocal fold atrophy (VFA) is associated with aging and Parkinson's disease (PD). Clinical diagnosis of VFA depends on several visual\u2010perceptual laryngostroboscopy findings that are inherently subjective. The purpose of this study was to use <jats:italic>quantitative<\/jats:italic> measurements to; (1) examine the relationships between VFA and dysphonia severity and (2) evaluate differences in VFA in patients with age\u2010related VFA versus PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six patients &gt;60\u2009years of age with VFA were included in this retrospective cohort study. Demographic information, medical history, Consensus Auditory\u2010Perceptual Evaluation of Voice (CAPE\u2010V), Voice Handicap Index\u201010 (VHI\u201010), and still images from the stroboscopic exam were obtained. Image J\u2122 was used to measure VFA, including bowing index (BI), normalized glottal gap area, and normalized mucosal wave amplitude. Pearson's correlation was used to evaluate the relationship between VFA, CAPE\u2010V, and VHI\u201010. <jats:italic>t<\/jats:italic>\u2010Tests and multivariate linear regression were used to compare VFA measures by dysphonia severity (CAPE\u2010V &lt;30 vs. &gt;30) and diagnosis (age\u2010related vocal atrophy [ARVA] and PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BI was positively correlated with CAPE\u2010V. Patients with CAPE\u2010V &gt;30 had a significantly larger BI compared to those with CAPE\u2010V &lt;30. Patients with PD had significantly larger BI than those with ARVA. Diagnosis of PD also predicted a larger BI after controlling for age and CAPE\u2010V.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Quantitative measures supported an association between bowing severity and dysphonia severity in patients with PD and ARVA. A PD diagnosis significantly predicted more severe BI. These findings demonstrate the potential utility of BI. Quantitative VFA measures might also provide insight into the mechanisms of ARVA and dysphonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 133:1462\u20131469, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30394","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T12:21:55Z","timestamp":1663330915000},"page":"1462-1469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Quantification of Vocal Fold Atrophy in Age\u2010Related and Parkinson's Disease\u2010Related Vocal Atrophy"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4080-5597","authenticated-orcid":false,"given":"Hans C.","family":"Baertsch","sequence":"first","affiliation":[{"name":"Keck School of Medicine University of Southern California  Los Angeles California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel K.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department Otolaryngology Head and Neck Surgery University of Washington  Seattle Washington U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-3909","authenticated-orcid":false,"given":"John P.","family":"Giliberto","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department Otolaryngology Head and Neck Surgery University of Washington  Seattle Washington U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Dixon","sequence":"additional","affiliation":[{"name":"Elson S Floyd College of Medicine Washington State University  Spokane Washington U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert L.","family":"Merati","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department Otolaryngology Head and Neck Surgery University of Washington  Seattle Washington U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Sauder","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department Otolaryngology Head and Neck Surgery University of Washington  Seattle Washington U.S.A."},{"name":"Speech and Hearing Sciences University of Washington  Seattle Washington U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13559"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00915.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000540"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9924(79)90021-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1980.00790270013003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100506"},{"issue":"9","key":"e_1_2_6_8_1","first-page":"542","article-title":"Speech and voice disorders in Parkinson's disease","volume":"51","author":"Martnez\u2010S\u00e1nchez F","year":"2010","journal-title":"Rev Neurol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000266286"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091729"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199202000-00007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22397"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25043"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25398"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12725"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.12.029"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.19020044"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.0409"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710600702"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2020.05.027"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2014.10.017"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200111000-00029"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2012.12.007"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2015.05.018"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200409000-00009"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360(2010\/09-0105)"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24889"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2013.10.023"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28158"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26409"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2021.07.002"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.3672686"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00475.2016"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874609812666190603165746"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.30394","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:05:41Z","timestamp":1692630341000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.30394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,16]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/lary.30394"],"URL":"https:\/\/doi.org\/10.1002\/lary.30394","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,16]]},"assertion":[{"value":"2022-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}