{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:33:31Z","timestamp":1790606011143,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004951","name":"Atat\u00fcrk \u00dcniversitesi","doi-asserted-by":"publisher","award":["TSA\u20102022\u201010486"],"award-info":[{"award-number":["TSA\u20102022\u201010486"]}],"id":[{"id":"10.13039\/501100004951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to employ biochemical, histopathological, and immunohistochemical methods to reveal the effectiveness of hesperidin and thymol in preventing radiotherapy\u2010associated submandibular gland injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 48 female Sprague Dawley rats were randomly assigned into six groups of eight animals each. Group 1 represented the control group. Group 2 was regarded as hesperidin Group, and the rats received only hesperidin. Group 3 was regarded as thymol Group, and the rats received only thymol. Group 4 was regarded as a Radiotherapy Group, and the rats were exposed to radiotherapy at a dose of 15\u2009Gy. Group 5 was regarded as hesperidin\u2009+\u2009Radiotherapy Group, and rats received hesperidin at a dose of 100\u2009mg\/kg daily for 1\u2009week prior to radiotherapy exposition. Group 6 was regarded as thymol\u2009+\u2009Radiotherapy Group, and rats received thymol at a dose of 100\u2009mg\/kg daily for 1\u2009week prior to radiotherapy exposition. Rats were sacrificed after radiotherapy and submandibular glands were dissected for biochemical and immunohistochemical evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We have shown that, thanks to their strong antioxidant and anti\u2010inflammatory properties, hesperidin and thymol minimize the damage caused by radiation toxicity by decreasing oxidant levels and increasing antioxidant enzyme levels in the submandibular gland. We found that thymol showed more protective activity than hesperidin in terms of effectiveness on radiation toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hesperidin and thymol exhibit histopathological, immunochemical, and biochemical protection against radiation\u2010related submandibular gland injury. To our knowledge, this is the first study in the literature in this field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>N\/A <jats:italic>Laryngoscope<\/jats:italic>, 133:1885\u20131892, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30405","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T18:24:39Z","timestamp":1663957479000},"page":"1885-1892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Protective Efficacy of Hesperidin and Thymol on Radiation\u2010Induced Submandibular Gland Damage"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9588-1725","authenticated-orcid":false,"given":"Muhammed Sedat","family":"Sakat","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine Ataturk University  Erzurum 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