{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:47:54Z","timestamp":1792237674969,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our study aims to evaluate the effectiveness of mastoid obliteration compared to the canal wall up (CWU) technique in cholesteatoma surgery based on the systematic review of the literature and the meta\u2010analysis of the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The systematic search was performed in four major databases (MEDLINE, Web of Science, Embase, and CENTRAL) on October 14, 2021. Studies comparing the CWU technique and mastoid obliteration were included. The exclusion criteria were less than 12\u2009months follow\u2010up, congenital cholesteatoma, indefinite description of the surgical method, and animal studies. The protocol was registered on Prospero (registration number: CRD42021282485). The risk of bias was evaluated with the ROBINS\u2010I tool. Residual and recurrent disease proportions as primary outcomes, quality of life, ear discharge, infection rates, hearing results, and operation time as secondary outcomes were analyzed. In the quantitative synthesis, the random effect model was used, and heterogeneity was identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 11 articles with 2077 operations' data were found eligible. All the identified studies were retrospective cohorts. The odds of pooled residual and recurrent disease proportion were significantly lower in the obliteration group compared to CWU (OR\u00a0=\u00a00.45, CI:0.28;0.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014). However, when separated, the proportion of ears with recurrent (OR\u00a0=\u00a00.41, CI:0.11;1.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.140) or residual (OR\u00a0=\u00a00.59, CI:0.23, 1.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.207) disease did not show a significant difference, even though the odds were quite similar. The qualitative synthesis identified no significant difference in the secondary outcomes, but obliteration elongated the operation time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mastoid obliteration significantly decreased the proportion of residual and recurrent cholesteatoma in pooled analyses compared to the CWU technique with low\u2010quality of data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      NA\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 133:1297\u20131305, 2023\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.30413","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T09:13:58Z","timestamp":1664356438000},"page":"1297-1305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Mastoid Obliteration Decreases the Recurrent and Residual Disease: Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2939-060X","authenticated-orcid":false,"given":"Kata","family":"Ill\u00e9s","sequence":"first","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Bajcsy\u2010Zsilinszky Hospital  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanni Ad\u00e9l","family":"Meznerics","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanni","family":"Dembrovszky","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute for Translational Medicine Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Feh\u00e9rv\u00e1ri","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Biomathematics and Informatics University of Veterinary Medicine  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"B\u00e1nv\u00f6lgyi","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezs\u0151","family":"Csupor","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute for Translational Medicine Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Institute of Clinical Pharmacy, Faculty of Pharmacy University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute for Translational Medicine Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Division of Pancreatic Diseases Heart and Vascular Center, Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Bajcsy\u2010Zsilinszky Hospital  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988209000616"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2006.08.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100093221"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6815-3-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3280-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17563"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-191112000-00007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/01455613211042946"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23759"},{"key":"e_1_2_6_11_1","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane handbook for systematic reviews of interventions","volume":"10","author":"Cumpston M","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2017.3363"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700616"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003107347"},{"key":"e_1_2_6_17_1","volume-title":"The Oxford 2011 Levels of Evidence Table","author":"Jeremy Howick ICJLL","year":"2011"},{"issue":"4","key":"e_1_2_6_18_1","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel N","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114447"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228020101000602"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1482"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.6028\/jres.087.022"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.11"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1410"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010247"},{"key":"e_1_2_6_27_1","unstructured":"Team RC.R: A language and environment for statistical computing.R Foundation for Statistical Computing.2022."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"key":"e_1_2_6_29_1","unstructured":"SchwarzerG.Meta: General Package for Meta\u2010Analysis. R package version 5.2\u20130. 2022."},{"key":"e_1_2_6_30_1","unstructured":"CuijpersP FurukawaT EbertDD.dmetar: Companion R Package for the Guide Doing Meta\u2010Analysis in R.2021."},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198408000-00006"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697989"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510013782X"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2019.09.011"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003246"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215119002408"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215011909765"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3370-2"},{"issue":"4","key":"e_1_2_6_39_1","first-page":"247","article-title":"Surgical treatment of cholesteatoma: a comparison of three techniques","volume":"11","author":"Toner JG","year":"1990","journal-title":"Am J Otol"},{"key":"e_1_2_6_40_1","article-title":"Radiological follow\u2010up after the bony obliteration Tympanoplasty in detecting residual Cholesteatoma: towards an optimal postoperative MR imaging protocol","author":"Toom HFE","journal-title":"Otol Neurotol"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414523562"},{"issue":"6","key":"e_1_2_6_42_1","first-page":"456","article-title":"Recurrence rate related to observation time","volume":"9","author":"Tos M","year":"1988","journal-title":"Am J Otol"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.104666"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001353"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215118000890"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2018.11.004"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.12.031"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215117000299"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2019.7038"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200110000-00009"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200210000-00013"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215121001195"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.30413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T11:04:53Z","timestamp":1692615893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.30413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/lary.30413"],"URL":"https:\/\/doi.org\/10.1002\/lary.30413","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]},"assertion":[{"value":"2022-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}