{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:16:13Z","timestamp":1773198973855,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["DP003906"],"award-info":[{"award-number":["DP003906"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["DP006312"],"award-info":[{"award-number":["DP006312"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U58 DP000835"],"award-info":[{"award-number":["U58 DP000835"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U58 DP006312"],"award-info":[{"award-number":["U58 DP006312"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objective\/Hypothesis<\/jats:title><jats:p>Oral cancers in the US\u2010affiliated Pacific Islands are poorly described despite disproportionately higher incidences in certain jurisdictions. This study attempts to better characterize the incidence, staging, and management of oral cancers in this region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective Epidemiological Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was conducted across the US\u2010affiliated Pacific Islands between 2007 and 2019. Patient data were obtained for individuals with primary head and neck cancers from the Pacific Regional Central Cancer Registry database. All cohorts were age\u2010adjusted to the 2000 US Standard Population. Further analysis was performed on oral cavity cancers due to their clear predominance within the sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 585 patients with primary head and neck cancers were included. The average age was 54.5\u2009\u00b1\u200912.9\u2009years, and most patients were male (76.8%). Oral cancer subsite analysis revealed the proportional incidence of buccal mucosa was higher in 5 of 9 jurisdictions when compared with the United States (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Tongue and lip cancers were not found to have significantly higher incidence proportions. Patients in the Pacific Islander group were less likely to be detected at earlier stages for cancers of the cheek and other mouth (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), tongue (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and lips (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared with the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Many Pacific Island populations are burdened with higher incidences of oral cancer with later staging. Further investigation is recommended to evaluate oral cancer\u2010related outcomes and mortality in this region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 133:1899\u20131905, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30419","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T12:49:24Z","timestamp":1664282964000},"page":"1899-1905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oral Cancer Disparities in the Outer <scp>US<\/scp>\u2010affiliated Pacific Islands"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4427-7792","authenticated-orcid":false,"given":"Kurtis","family":"Young","sequence":"first","affiliation":[{"name":"Department of Surgery University of Hawai'i at M\u0101noa John A. Burns School of Medicine  Honolulu Hawai USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Bulosan","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hawai'i at M\u0101noa John A. Burns School of Medicine  Honolulu Hawai USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janos","family":"Baksa","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hawai'i at M\u0101noa John A. Burns School of Medicine  Honolulu Hawai USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngju","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hawai'i at M\u0101noa John A. Burns School of Medicine  Honolulu Hawai USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee E.","family":"Buenconsejo\u2010Lum","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Hawai'i at M\u0101noa John A. Burns School of Medicine  Honolulu Hawai USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Birkeland","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology University of California Davis Medical Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/1355785022000060736"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2015.302921"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2017.08.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1679-45082018AO4248"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"19","article-title":"Areca (betel) nut chewing practices in Micronesian populations","volume":"3","author":"Paulino YC","year":"2011","journal-title":"Hawaii J Public Health"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30511-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30400-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30414-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0042-96862005000900010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272684X15581344"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.177.2.174"},{"key":"e_1_2_7_14_1","unstructured":"U.S. Cancer Statistics Working Group.U.S. Cancer Statistics Data Visualizations Tool based on 2020 submission data (1999\u20132018). U.S. Department of Health and Human Services Centers for Disease Control and Prevention and National Cancer Institute. Released in June 2021.www.cdc.gov\/cancer\/dataviz"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6915a1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2020.06.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2017.07.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042759"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92109-s"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00124784-200701000-00009"},{"issue":"11","key":"e_1_2_7_21_1","first-page":"4","article-title":"Health care for Micronesians and constitutional rights","volume":"70","author":"Shek D","year":"2011","journal-title":"Hawaii Med J"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-020-00413-w"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420934846"},{"key":"e_1_2_7_24_1","unstructured":"Key statistics for oral cavity and oropharyngeal cancers.American Cancer Society. Accessed 12\/23\/21 https:\/\/www.cancer.org\/cancer\/oral-cavity-and-oropharyngeal-cancer\/about\/key-statistics.html"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2018.19.8.2165"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.04.014"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172752"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20122940"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239219"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.29765"},{"key":"e_1_2_7_31_1","unstructured":"Resouce limitations.Pacific Cancer Programs.https:\/\/pacificcancer.org\/"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.30419","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T03:45:21Z","timestamp":1692243921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.30419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,27]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/lary.30419"],"URL":"https:\/\/doi.org\/10.1002\/lary.30419","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,27]]},"assertion":[{"value":"2022-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}