{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:48:48Z","timestamp":1760986128408,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the prevalence of hypopharyngeal carcinoma (HPC) with synchronous second primary malignancies (Syn\u2010SPMs), their impact on clinical outcomes, and associated risk factors in the image\u2010enhanced endoscopy era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively analyzed 673 patients newly diagnosed with HPC at our cancer center between 2009 and 2019. The patients were divided into three groups: (a) no second primary malignancies (N\u2010SPMs, <jats:italic>n<\/jats:italic>\u00a0=\u2009533); (b) synchronous carcinoma in situ (Syn\u2010Tis, <jats:italic>n<\/jats:italic>\u00a0=\u200960); (c) synchronous invasive tumors (Syn\u2010invasive, <jats:italic>n<\/jats:italic>\u00a0=\u200980). Propensity score matching was conducted to balance the N\u2010SPMs and Syn\u2010invasive groups at a 3:1 ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most (96.1%) underwent pretreatment esophagogastroduodenoscopy evaluation with image\u2010enhanced endoscopy. The incidence rates were: Syn\u2010SPMs, 20.8%; Syn\u2010Tis, 8.9%; Syn\u2010invasive, 11.9%. At a median follow\u2010up of 66.7\u2009months, the Syn\u2010Tis and N\u2010SPMs groups had a similar 5\u2010year overall survival (OS; 45.6% vs. 44.5%; hazard ratio [HR], 0.956; 95% confidence interval [CI], 0.660\u20131.385; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.806). Compared to the N\u2010SPMs group, the Syn\u2010invasive group had poorer 5\u2010year OS (27.0% vs. 52.9%; HR, 2.059; 95% CI, 1.494\u20132.839; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Alcohol consumption was significantly associated with Syn\u2010SPMs occurrence (odds ratio, 2.055, 2.414, and 3.807 for light, intermediate, and heavy drinkers, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of Syn\u2010SPMs among patients with HPC was high. Syn\u2010invasive SPMs decreased the survival of patients with HPC. Routine screening with image\u2010enhanced endoscopy should be recommended to detect early\u2010stage SPMs, especially for heavy alcohol drinkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 133:1906\u20131913, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30420","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T12:43:31Z","timestamp":1667393011000},"page":"1906-1913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synchronous Second Primary Cancers of Hypopharyngeal Carcinoma in the Image\u2010Enhanced Endoscopy Era"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-9644","authenticated-orcid":false,"given":"Xi","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research 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Surgical Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-0708","authenticated-orcid":false,"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical 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