{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:40:57Z","timestamp":1775065257184,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>COVID\u201019 is causing a wide range of clinical manifestations. Severe complications and long\u2010lasting sequelae have been identified. Thus, olfactory disorders are reported in up to 86% of cases in mild and moderate COVID\u201019 infections. We present the first study comparing simple and complex post\u2010COVID\u201019 cases with matched non\u2010COVID\u201019 post\u2010infectious smell and taste disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 328 patients were recruited from the University Clinic for Flavour, Balance and Sleep, Ear\u2010nose\u2010throat Department, Goedstrup Hospital, Denmark. A non\u2010COVID \u201019 post\u2010infectious population of 148 individuals was identified from the Redcap database, and was matched by duration of smell and taste disorders. Post\u2010COVID\u201019 patients were divided into 99 patients with simple smell and taste disorders (only suffering from smell and taste disorders after COVID\u201019); and (81 patients with complex smell and taste disorder plus several other post\u2010COVID\u201019 complaints). Besides patient\u2010reported outcome measures (PROM) questionnaires and quality of life score (QoL), ear\u2010nose\u2010throat examination, Mini\u2010Mental State Examination (MMSE), orthonasal smell test (Sniffing's sticks), retronasal quick test, and taste screening were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cases with post\u2010COVID\u201019\u2010related smell and taste disorders deviated from non\u2010COVID\u201019 post\u2010infectious cases; the patients were younger, had a lower occurrence of anosmia\/ageusia, and had higher overall smell test scores. In contrast, patients with post\u2010COVID\u201019\u2010related smell and taste disorders more frequently complained of distorted senses. Parosmia and phantosmia were more prevalent among patients with simple post\u2010COVID\u201019 complaints than among complex cases and their QoL were more negatively affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Smell and taste function differ significantly between post\u2010COVID\u201019 and other non\u2010COVID\u201019 post\u2010viral cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p><jats:bold>3<\/jats:bold> <jats:italic>Laryngoscope<\/jats:italic>, 133:169\u2013174, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30453","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T11:11:54Z","timestamp":1666955514000},"page":"169-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Long\u2010Term <scp>COVID<\/scp>\u201019 Smell and Taste Disorders Differ Significantly from Other Post\u2010Infectious Cases"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4096-7112","authenticated-orcid":false,"given":"Dovile","family":"Stankevice","sequence":"first","affiliation":[{"name":"University Clinic for Flavour, Balance and Sleep, ENT Department Goedstrup Hospital  Herning Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-6920","authenticated-orcid":false,"given":"Alexander Wieck","family":"Fjaeldstad","sequence":"additional","affiliation":[{"name":"University Clinic for Flavour, Balance and Sleep, ENT Department Goedstrup Hospital  Herning Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus N Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Agergaard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Ovesen","sequence":"additional","affiliation":[{"name":"University Clinic for Flavour, Balance and Sleep, ENT Department Goedstrup Hospital  Herning Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus N Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Danish serum institute. 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