{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:30:39Z","timestamp":1792272639856,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate weight gain in children post\u2010thyroidectomy and identify predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Charts from patients at a tertiary health care facility who underwent total thyroidectomy from 2014 to 2020 were reviewed for Body Mass Index <jats:italic>z<\/jats:italic>\u2010scores (BMIz) at the time of thyroidectomy and at 1 and 2\u2010year post\u2010operation intervals. Patient demographic information, comorbidities, pre\u2010 and postoperative thyroid stimulating hormone, and postoperative free T4 levels were also extracted. Patients with other known endocrine abnormalities, chronic kidney disease, or without sufficient follow\u2010up were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 56 patients (ages 3\u201317\u2009years old) met the inclusion criteria (<jats:italic>n<\/jats:italic>\u00a0=\u00a017 Graves' disease; <jats:italic>n<\/jats:italic>\u00a0=\u00a039 presumed cancer). Over the first year, average BMIz significantly increased in patients with Graves' disease (\u2206BMIz\u00a0=\u00a00.45\u2009\u00b1\u20090.77, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), Hispanic ethnicity (\u2206BMIz\u00a0=\u00a00.43\u2009\u00b1\u20090.68, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), Medicaid\/no insurance coverage (\u2206BMIz\u00a0=\u00a00.33\u2009\u00b1\u20090.74, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038), age &lt;13\u2009years at thyroidectomy (\u2206BMIz\u00a0=\u00a00.35\u2009\u00b1\u20090.68, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016), and persistent postoperative hypothyroidism (\u2206BMIz\u00a0=\u00a00.41\u2009\u00b1\u20090.41, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012). These changes remained significant after the second year. Age at thyroidectomy correlated negatively with \u2206BMIz only after the first year (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.40, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). Regression analysis, controlling for Graves' status, persistent postoperative hypothyroidism, and insurance coverage, identified age at thyroidectomy as a significant predictor of \u2206BMIz after the first year (<jats:italic>b<\/jats:italic>\u00a0=\u00a0\u22120.06, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) and Hispanic ethnicity as a significant predictor after the second year (<jats:italic>b<\/jats:italic>\u00a0=\u00a00.60, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A small increase in BMIz post\u2010thyroidectomy was observed across several patient subgroups. Younger age at thyroidectomy and Hispanic ethnicity were associated with increased BMIz in the first 2\u2009years post\u2010thyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level 4 \u2010 Historically controlled cohort <jats:italic>Laryngoscope<\/jats:italic>, 133:1518\u20131523, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30532","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T11:05:25Z","timestamp":1671534325000},"page":"1518-1523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Total Thyroidectomy and Subsequent Weight Gain in Pediatric Populations"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8759-3368","authenticated-orcid":false,"given":"Evan R.","family":"Edwards","sequence":"first","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8816-7141","authenticated-orcid":false,"given":"Inbal","family":"Hazkani","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5569-7795","authenticated-orcid":false,"given":"Eli","family":"Stein","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0339-0166","authenticated-orcid":false,"given":"Jami L.","family":"Josefson","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Division of Pediatric Endocrinology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-1661","authenticated-orcid":false,"given":"Jill H.","family":"Samis","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Division of Pediatric Endocrinology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-8091","authenticated-orcid":false,"given":"Jennifer L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Division of Pediatric Endocrinology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-549X","authenticated-orcid":false,"given":"Jeffrey","family":"Rastatter","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816677527"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/wjps-2020-000185"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2020.11.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13493"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1996.441788000.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.12.5338"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0602"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa754"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01543.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12112"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-014-2634-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1015-9584(09)60397-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-055366"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.6803"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2013"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18189434"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.11.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0266"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-973071"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02024-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.14590"},{"key":"e_1_2_6_23_1","unstructured":"2020\u20132021 National Survey of Children's Health (NSCH) data query.Data Resource Center for Child and Adolescent Health supported by the U.S. Department of Health and Human Services Health Resources and Services Administration (HRSA) Maternal and Child Health Bureau (MCHB). Accessed 10\/14\/2022.www.childhealthdata.org"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941738119870192"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810392328"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.12005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamaoto.252"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1160-5"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.30532","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:05:56Z","timestamp":1692630356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.30532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/lary.30532"],"URL":"https:\/\/doi.org\/10.1002\/lary.30532","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"assertion":[{"value":"2022-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}