{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:25:52Z","timestamp":1783650352880,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine oncologic outcomes for patients with T4b sinonasal squamous cell carcinoma (SNSCC) treated with either surgery plus radiotherapy or definitive radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Between January 1999 and December 2016, 85 patients with T4b SNSCC were analyzed retrospectively, there were 54 who received surgery plus radiotherapy (S\u2009+\u2009RT group) \u00b1 chemotherapy and 31 with definitive radiotherapy (RT group) \u00b1 chemotherapy. A 1: 2 propensity score matching (PSM) was performed to balance clinical factors and match patients. Kaplan\u2013Meier method and Cox proportional hazard model were used to determine risk factors on survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time was 76.7\u2009months. The cumulative rates of locoregional control (LRC), distant metastasis\u2010free survival (DMFS), cancer\u2010specific survival (CSS), and overall survival (OS) at 5\u2009years for entire cohort were 44.6%, 33.1%, 38.8%, and 33.9% respectively. After PSM, a total of 50 patients in S\u2009+\u2009RT group and 25 patients in RT group were analyzed. The 5\u2010year LRC, DMFS, CSS, and OS between S\u2009+\u2009RT and RT group were 58.6% versus 27.5% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.035), 42.8% versus 20.0% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006), 50.3% versus 22.0% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005), 44.5% veruss 20.0% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). The 5\u2010year survival rates with orbital retention between groups were 32.7% and 15.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.080. Multivariate Cox analysis revealed non\u2010surgical therapy (HR\u00a0=\u00a03.678, 95%CI 1.951\u20136.933) and invasion of cranial nerves (other than maxillary division of trigeminal nerves) (HR\u00a0=\u00a02.596, 95%CI 1.217\u20135.535) were associated with decreased OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The inclusion of surgery in the multimodal management of T4b SNSCC might confer a survival benefit. Further prospective studies comparing the oncologic outcomes of S\u2009+\u2009RT with RT are warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 133:2222\u20132231, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30545","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T09:55:07Z","timestamp":1672394107000},"page":"2222-2231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["T4b Sinonasal Squamous Cell Carcinoma: Surgery Plus Radiotherapy May Contribute to Prolonged Survival"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9078-6817","authenticated-orcid":false,"given":"Zekun","family":"Wang","sequence":"first","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghu","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bining","family":"Yang","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-0708","authenticated-orcid":false,"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Chen","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Wang","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runye","family":"Wu","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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