{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:29:53Z","timestamp":1787869793465,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the safety and clinical effectiveness of transoral laser microsurgery (TLM) with potassium\u2010titanyl\u2010phosphate (KTP) laser ablation for glottic neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Source<\/jats:title><jats:p>MEDLINE via PubMed, SCOPUS, Web of Science, and Cochrane Library.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>A systematic review and meta\u2010analysis of studies assessing the safety and efficacy of KTP laser therapy in patients with early\u2010stage glottic neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies were included. After an average follow\u2010up of 3.3\u2009years, the overall survival and disease\u2010free survival for patients who underwent KTP were 90.7% (95% CI 85%\u201396.5%) and 98.5% (95% CI 97.3%\u201399.8%), respectively. In the single\u2010arm meta\u2010analysis, the pooled estimate of recurrence was 7.7% (95% CI 3.4%\u201312%). The overall voice handicap index (VHI) estimate attributed to KTP in the single\u2010arm meta\u2010analysis was 6.76 (95% CI [3.05, 10.48]) and 5.21 (95% CI [2.86, 7.56]) within 6\u2009months and after a one\u2010year follow\u2010up, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>KTP laser ablation is a safe and effective method for treating patients with early glottic neoplasms. <jats:italic>Laryngoscope<\/jats:italic>, 133:1806\u20131814, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30547","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T12:25:41Z","timestamp":1673007941000},"page":"1806-1814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes of <scp>KTP<\/scp> Laser Ablation in Glottic Neoplasms: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-0781","authenticated-orcid":false,"given":"Mustafa","family":"Suppah","sequence":"first","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2010Head and Neck Surgery Mayo Clinic Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Kamal","sequence":"additional","affiliation":[{"name":"Hillman Cancer Center University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Karle","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology\u2010Head and Neck Surgery Mayo Clinic Arizona  Phoenix Arizona 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