{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:30:35Z","timestamp":1784860235387,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare outcomes between two standard\u2010of\u2010care anesthesia regimens for operative laryngoscopy: general anesthesia with a neuromuscular blocking agent (NMBA) versus remifentanil and propofol (non\u2010NMBA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, single\u2010blinded, randomized controlled trial at a tertiary care center. Patients were randomized to either anesthesia using rocuronium (NMBA) or with remifentanil\/propofol infusion alone (non\u2010NMBA). Intraoperative impressions, anesthesia data, and post\u2010operative patient surveys were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients who underwent suspension laryngoscopy from 2020 to 2022 were included (25 female, 36 male, ranging 20\u201381\u2009years). Thirty patients were enrolled in the NMBA arm and 31 patients in the non\u2010NMBA arm. Heart rate and mean arterial pressure were higher in the NMBA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Patients in the non\u2010NMBA group were more likely to require vasopressors (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04, RR\u00a0=\u00a03.08 [0.86\u201311.05]). Surgeons were more frequently satisfied with conditions in the NMBA group (86.7%) compared to the non\u2010NMBA group (58.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Procedures were more likely to be paused due to movement in the non\u2010NMBA group (45.1%) compared to the NMBA group (16.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.03, RR\u00a0=\u00a02.26 [1.02\u20134.99]). Patients in the non\u2010NMBA group were more likely to endorse myalgia the week after surgery (44%) compared to the NMBA group (8.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and reported higher average pain levels on a 0\u201310 pain scale (3.7) compared to the paralysis group (2.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anesthesia with rocuronium was associated with better intraoperative conditions and postoperative pain compared to anesthesia with remifentanil\/propofol. Remifentanil\/propofol were associated with lower blood pressure and suppression of laryngoscopy\u2010associated tachycardia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2 <jats:italic>Laryngoscope<\/jats:italic>, 133:2654\u20132664, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30571","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T10:45:16Z","timestamp":1675075516000},"page":"2654-2664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paralysis Versus Non\u2010Paralysis Anesthesia for Operative Laryngoscopy: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3719-3614","authenticated-orcid":false,"given":"Jackie","family":"Yang","sequence":"first","affiliation":[{"name":"NYU Grossman School of Medicine  New York New York 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