{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:47:59Z","timestamp":1784990879807,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sinonasal inverted papillomas (IP) can undergo transformation into IP\u2010squamous cell carcinomas (IP\u2010SCC). More aggressive treatment plan should be established when IP\u2010SCC is suspected. Nevertheless, inaccuracy of the preoperative punch biopsy results to detect IP\u2010SCC from IP raises the need for an additional strategy. The present study aimed to investigate significant clinicoradiological remarks associated with IP\u2010SCC than IP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Postoperative surgical specimens obtained from patients with confirmed IP or IP\u2010SCC at a single tertiary medical center from 1997 to 2018 were retrospectively evaluated. Patients' demographic and clinical characteristics, preoperative in\u2010office punch biopsy results, and preoperative computed tomography (CT) or magnetic resonance images were reviewed. Univariate and multivariate analyses were performed to assess the odds ratio (OR) associated with IP\u2010SCC. The area under the curve (AUC) in the receiver Operating Characteristic (ROC) curve was calculated in the prediction model to discriminate IP\u2010SCC from IP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 44 IP\u2010SCC and 301 patients with IP. The diagnostic sensitivity of in\u2010office punch biopsy to detect IP\u2010SCC was 70.7%. Multivariate analysis showed that factors significantly associated with IP\u2010SCC included tobacco smoking &gt;10PY (adjusted\u2010OR [aOR]: 4.1), epistaxis (aOR: 3.4), facial pain (aOR: 4.2), bony destruction (aOR: 37.6), bony remodeling (aOR: 36.3), and invasion of adjacent structures (aOR: 31.6) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Combining all significantly related clinicoradiological features, the ability to discriminate IP\u2010SCC from IP reached an AUC of 0.974.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IP patients with a history of tobacco smoking, facial pain, epistaxis, and bony destruction, remodeling, or invasion of an adjacent structure on preoperative images may be at higher risk for IP\u2010SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 133:2502\u20132510, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30583","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T08:44:01Z","timestamp":1674463441000},"page":"2502-2510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preoperative Prediction of Sinonasal Inverted Papilloma\u2010associated Squamous Cell Carcinoma (<scp>IP\u2010SCC<\/scp>)"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1746-3266","authenticated-orcid":false,"given":"Marn Joon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Inha University Medical Center, Inha University School of Medicine  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-2214","authenticated-orcid":false,"given":"Wonki","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-6867","authenticated-orcid":false,"given":"Ji Heui","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-5415","authenticated-orcid":false,"given":"Yoo\u2010Sam","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7631-0388","authenticated-orcid":false,"given":"Yong Ju","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4529-0254","authenticated-orcid":false,"given":"Myeong Sang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head &amp; Neck Surgery Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199503000-00011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200103000-00001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000205"},{"key":"e_1_2_6_5_1","first-page":"263","article-title":"Histological features and malignant transformation of inverted papilloma. 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