{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:57:08Z","timestamp":1775087828393,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is prevalent in people with cystic fibrosis (PwCF) and is often refractory to treatments. Uncontrolled CRS might negatively impact the lower airways and the quality of life. The aim of this study is to evaluate the burden of cystic fibrosis (CF)\u2010related CRS in the era of CF transmembrane conductance regulator (CFTR) modulators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult PwCF were asked to fill in a questionnaire on sinonasal complaints, they underwent a nasal endoscopy, bacteriological sampling, and a CT scan. Afterwards, these outcome measures were compared between patients treated with and without modulators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 122 included patients, CRS was present in 83%. CFTR modulators were prescribed in 48% of the patients, with a median of 10\u2009months since the start of the treatment. Subjectively, the median SNOT\u201022 score was 16\/110. Objectively, a median Lund\u2010Kennedy score of 6\/12 and modified Lund\u2010Mackay score of 10\/24 were observed. No correlation could be found between SNOT\u201022 score and other outcome measures including endoscopy and radiology. Altogether, 21% of the patients had controlled disease. When comparing patients treated with and without modulators, significantly lower CT scores (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0018) and less bacterial colonization (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0082) were observed in patients receiving modulators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CF\u2010CRS is highly prevalent in our cohort and only the minority of PwCF has a well\u2010controlled disease. A multidisciplinary ENT\u2010pneumology clinic would be beneficial, as there is a high discrepancy between patient\u2010reported symptoms and the extent of the disease. CFTR modulators are promising, as lower CT scores and less bacterial colonization were observed in the modulator group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level 3 <jats:italic>Laryngoscope<\/jats:italic>, 133:2898\u20132909, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30642","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T11:42:18Z","timestamp":1678707738000},"page":"2898-2909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Upper Airway Disease in Adults with Cystic Fibrosis in the Era of <scp>CFTR<\/scp> Modulators"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3834-6029","authenticated-orcid":false,"given":"Saartje","family":"Uyttebroek","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck surgery UZ Leuven  Leuven Belgium"},{"name":"Department of Neurosciences, Experimental Otorhinolarygology, Rhinology Research KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieven","family":"Dupont","sequence":"additional","affiliation":[{"name":"Department of Pneumology UZ Leuven  Leuven Belgium"},{"name":"Department of Chronic Diseases and Metabolism, Respiratory Diseases and Thoracic Surgery KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Jorissen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck surgery UZ Leuven  Leuven Belgium"},{"name":"Department of Neurosciences, Experimental Otorhinolarygology, Rhinology Research KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5325-7956","authenticated-orcid":false,"given":"Laura","family":"Van Gerven","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck surgery UZ Leuven  Leuven Belgium"},{"name":"Department of Neurosciences, Experimental Otorhinolarygology, Rhinology Research KU Leuven  Leuven Belgium"},{"name":"Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WanyamaSS DaneauG DupontL.Belgian cystic fibrosis registry [BCFR]: Annual Report.2020."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.04.013"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"32","article-title":"Chronic rhinosinusitis in cystic fibrosis: diagnosis and medical management","volume":"7","author":"Safi C","year":"2019","journal-title":"Med 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