{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:23:06Z","timestamp":1781011386456,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the impact of comorbid migraine on quality of life (QOL) in chronic rhinosinusitis (CRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 213 adult patients with CRS were recruited. All participants completed the 22\u2010item Sinonasal Outcome Test (SNOT\u201022), from which total and validated nasal, ear\/facial pain, sleep, and emotional subdomain scores were calculated, and the 5\u2010dimension EuroQol general health questionnaire (EQ\u20105D), from which the visual analogue scale (VAS) and health utility value (HUV) were calculated. The presence of comorbid migraine was determined by a score of \u22654 on the 5\u2010item Migraine Screen Questionnaire (MS\u2010Q).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the participants, 36.2% were screened positive for having comorbid migraine. The mean SNOT\u201022 score was 64.9 (SD: 18.7) in participants with migraine and 41.5 (SD: 21.1) in participants without migraine (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The mean EQ\u20105D VAS and HUV were 60.2 (SD: 21.9) and 0.69 (SD: 0.18), respectively, in participants with migraine and 71.4 (SD: 19.4) and 0.84 (SD: 0.13), respectively, in participants without migraine (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for both). Higher ear\/facial pain (OR\u00a0=\u00a01.22, 95% CI: 1.10\u20131.36, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and sleep (OR\u00a0=\u00a01.11, 95% CI: 1.04\u20131.18, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) SNOT\u201022 subdomain scores were positively associated with migraine. The SNOT\u201022 item scores related to dizziness, reduced concentration, and facial pain, in descending order, were most associated with migraine. The presence of nasal polyps (OR = 0.24, 95% CI: 0.07 \u2010 0.80, p = 0.020) was negatively associated with migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Comorbid migraine may be relatively common amongst CRS patients, and its presence is associated with significantly worse QOL. Dizziness as a symptom in CRS patients may be particularly indicative of migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 133:3279\u20133284, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30662","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T10:35:39Z","timestamp":1679913339000},"page":"3279-3284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Burden of Migraine on Quality of Life in Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"133","author":[{"given":"Armo","family":"Derbarsegian","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-9492","authenticated-orcid":false,"given":"Sarah M.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-3508","authenticated-orcid":false,"given":"Katie M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-2325","authenticated-orcid":false,"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College 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