{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:50:03Z","timestamp":1770742203553,"version":"3.49.0"},"reference-count":60,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To define the role of hypothyroidism and other risk factors for unplanned readmissions after surgery for head and neck cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Nationwide Readmission Database (NRD) was used to identify patients who underwent surgery for mucosal head and neck cancer (oral cavity, oropharynx, larynx, and hypopharynx) between 2010 and 2017. Univariate and multivariate logistic regression were performed to determine patient, tumor, and hospital related risk factors for 30\u2010day readmission. Readmitted patients were stratified by preoperative diagnosis of hypothyroidism to compare readmission characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the 131,013 patients who met inclusion criteria, the readmission rate was 15.9%. Overall, 11.91% of patients had a preoperative diagnosis of hypothyroidism. After controlling for other variables, patients with a preoperative diagnosis of hypothyroidism had 12.2% higher odds of readmission compared to those without hypothyroidism (OR: 1.12, 1.03\u20131.22, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). Patients with hypothyroidism had different reasons for readmission, including higher rates of wound dehiscence, fistula, infection, and electrolyte imbalance. Among readmitted patients, the length of stay for index admission (mean 10.5\u2009days vs. 9.2\u2009days, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), readmission (mean 7.0 vs. 6.6\u2009days, <jats:italic>p<\/jats:italic>\u2009=\u20090.05), and total hospital charge were higher for hypothyroid patients ($137,742 vs. $119,831, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypothyroidism is an independent risk factor for 30\u2010day readmission following head and neck cancer resection. Furthermore, hypothyroid patients are more likely to be readmitted for wound complications, infection, and electrolyte imbalance. Targeted interventions should be considered for hypothyroid patients to decrease readmission rates and associated patient morbidity, potentially leading to earlier initiation of adjuvant treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 133:2988\u20132998, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30675","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T14:08:13Z","timestamp":1680012493000},"page":"2988-2998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hypothyroidism as an Independent Predictor of 30\u2010day Readmission in Head and Neck Cancer Patients"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-7211","authenticated-orcid":false,"given":"Sarah C.","family":"Nyirjesy","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songzhu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics and Center for Biostatistics The Ohio State University  320 Lincoln Tower, 1800 Cannon Drive Columbus Ohio 43210 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Judd","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"McCrary","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah N.","family":"Kuhar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice L.","family":"Farlow","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-5313","authenticated-orcid":false,"given":"Nolan B.","family":"Seim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W.","family":"Rocco","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0865-6149","authenticated-orcid":false,"given":"Stephen Y.","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-6536","authenticated-orcid":false,"given":"Catherine T.","family":"Haring","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27461"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.105039"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22711"},{"key":"e_1_2_7_6_1","unstructured":"RauJ.Medicare's readmission penalties hit new high. Kaiser Health News2016."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzv090"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24030"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24407"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.03.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26311"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817750373"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.06.010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6278-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr030"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmab027"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e328325a538"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12513"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0199"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1992.tb02130.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K06-062"},{"key":"e_1_2_7_22_1","unstructured":"NRD Overview.Healthcare Cost and Utilization Project (HCUP).https:\/\/www.hcup-us.ahrq.gov\/nrdoverview.jsp."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1705"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.06.022"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.02.004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23973"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818776633"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25107"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813500023"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22134"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26804"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2018.1197"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29903"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.053"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25019"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.4236\/ijcm.2019.1012053"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac215"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819835545"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-015-0929-6"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.07.003"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199411001-00001"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/124538"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.21037\/jss.2018.05.26"},{"issue":"24","key":"e_1_2_7_45_1","first-page":"3819","article-title":"Correlation of thyroid hormone with blood glucose and lipid metabolism in patients with type 2 diabetes mellitus","volume":"24","author":"Shi Y","year":"2018","journal-title":"Int Med Heal Guid News"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-1171"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0429"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041445"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0396.2005.00602.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radmp.2021.01.002"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.530680"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00287-5"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(03)00396-8"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.105117"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816671695"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.4048"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815570025"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420937044"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.533"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/wjo2.56"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1499"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T15:33:08Z","timestamp":1707319988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.30675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,28]]},"references-count":60,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/lary.30675"],"URL":"https:\/\/doi.org\/10.1002\/lary.30675","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,28]]},"assertion":[{"value":"2022-12-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}