{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:49:58Z","timestamp":1760986198273,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Treatment for primary hyperparathyroidism is parathyroidectomy. This study identifies the association between hypoalbuminemia (HA) and outcomes in patients undergoing parathyroidectomy for primary hyperparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort analysis utilized the 2006\u20132015 National Surgical Quality Improvement Program database. Current Procedure Terminology codes were used to identify patients undergoing parathyroidectomy for primary hyperparathyroidism. Prolonged length of stay (LOS) was defined as a duration of 2\u2009days or greater. Demographics and comorbidities were compared between HA (serum albumin &lt;3.5\u2009g\/dL) and non\u2010HA cohorts using chi\u2010square analysis. The independent effect of HA on adverse outcomes was analyzed using binary logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7183 cases with primary hyperparathyroidism were classified into HA (<jats:italic>n<\/jats:italic>\u2009=\u2009381) and non\u2010HA (<jats:italic>n<\/jats:italic>\u2009=\u20096802) cohorts. HA patients had increased complications, including renal insufficiency (0.8% vs. 0.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), sepsis (1.0% vs. 0.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), pneumonia (0.8% vs. 0.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.018), acute renal failure (1.0% vs. 0.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and unplanned intubation (1.3% vs. 0.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). HA patients had increased risk of death (1.6% vs. 0.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), prolonged LOS (40.9% vs. 6.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and any complication (5.5% vs. 1.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Adjusted binary logistic regression indicated HA patients experienced increased odds of progressive renal insufficiency (OR 18.396, 95% CI 1.844\u2013183.571, <jats:italic>p<\/jats:italic>\u2009=\u20090.013), prolonged LOS (OR 4.892; 95% CI 3.571\u20136.703; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), unplanned reoperation (OR 2.472; 95% CI 1.012\u20136.035; <jats:italic>p<\/jats:italic>\u2009=\u20090.047), and unplanned readmission (OR 3.541; 95% CI 1.858\u20136.748; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HA may be associated with adverse complications in patients undergoing parathyroidectomy for primary hyperparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 133:2035\u20132039, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30691","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T12:00:08Z","timestamp":1681300808000},"page":"2035-2039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Hypoalbuminemia in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4148-119X","authenticated-orcid":false,"given":"Imran M.","family":"Khawaja","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6804-6062","authenticated-orcid":false,"given":"Avneet","family":"Randhawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0013-9040","authenticated-orcid":false,"given":"Karandeep","family":"Randhawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owais M.","family":"Aftab","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6691-3131","authenticated-orcid":false,"given":"Roshan V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Department of Ophthalmology and Visual Science Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Department of Otolaryngology and Facial Plastic Surgery Saint Barnabas Medical Center \u2013 RWJ Barnabas Health  Livingston New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-2788","authenticated-orcid":false,"given":"Christina 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