{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:22:09Z","timestamp":1770337329486,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe swallowing and feeding\u2010tube outcomes in patients with high\u2010risk oropharyngeal cancer treated with trimodality therapy (TMT), including transoral robotic surgery (TORS) and adjuvant chemoradiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A chart review was conducted on patients with HPV+ OPSCC receiving TMT with TORS at an academic medical center from March 2010 to March 2021. Data collected included demographics, treatment, feeding tube placement, functional oral intake scale (FOIS) scores, and swallowing\u2010language pathology (SLP) evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 255 patients met selection criteria (mean age 61\u2009years, 88% male). Following intraoperative nasogastric tube (NG) placement, 31% remained NG tube dependent after 3\u2009weeks. A gastrostomy tube was placed in 19% of patients, and at 1\u2009year after end\u2010of\u2010treatment (EOT), 3.5% overall remained tube\u2010dependent. Mean FOIS scores were 6.9 (SD\u2009=\u20090.3) at pre\u2010operative visit, 2.6 (1.8) at first post\u2010operative visit, and 5.5 (1.5) after EOT. In the subset of patients with follow\u2010up longer than 2\u2009years (<jats:italic>n<\/jats:italic>\u2009=\u2009118), the mean FOIS was 6.1 (SD\u2009=\u20091.3) at most recent visit. Clinical signs of aspiration\/penetration were suspected on SLP evaluation in 18% of patients. These patients were subsequently evaluated with fiberoptic endoscopic evaluation of swallowing (FEES) and\/or barium swallow study, which confirmed signs of aspiration in 2.7% of patients overall. Delayed NG tube removal after 3\u2009weeks was predictive of (1) gastrostomy tube requirement and (2) clinical signs of aspiration on an SLP visit after EOT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Favorable functional and feeding\u2010tube outcomes are demonstrated in patients with HPV\u2010associated OPSCC undergoing TMT. In this single\u2010institution study, we found low rates of long\u2010term feeding tube dependence and high median FOIS following treatment. Review of routine SLP visits provides a detailed and easily accessible means for assessing swallowing function in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 133:3013\u20133020, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30714","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T12:40:25Z","timestamp":1683031225000},"page":"3013-3020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Functional Outcomes in Patients with Human Papillomavirus\u2010Associated\u00a0Oropharyngeal Squamous Cell Cancer Treated with Trimodality Therapy"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5619-6191","authenticated-orcid":false,"given":"Joseph S.","family":"Lu","sequence":"first","affiliation":[{"name":"Sidney Kimmel Medical College Thomas Jefferson University  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