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Lack of satisfactory preclinical models is one reason that treatments for these diseases are limited. We sought to assess the literature describing preclinical models of laryngeal papillomavirus infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>PubMed, Web of Science, and Scopus were searched from the inception of database through October 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Studies searched were screened by two investigators. Eligible studies were peer\u2010reviewed, published in English, presented original data, and described attempted models of laryngeal papillomavirus infection. Data examined included type of papillomavirus, infection model, and results including success rate, disease phenotype, and viral retention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After screening 440 citations and 138 full\u2010text studies, 77 studies published between 1923 and 2022 were included. Models used low\u2010risk HPV or RRP (<jats:italic>n<\/jats:italic>\u2009=\u200951 studies), high\u2010risk HPV or laryngeal cancer (<jats:italic>n<\/jats:italic>\u2009=\u200916), both low\u2010 and high\u2010risk HPV (<jats:italic>n<\/jats:italic>\u2009=\u20091), and animal papillomaviruses (<jats:italic>n<\/jats:italic>\u2009=\u20099). For RRP, 2D and 3D cell culture models and xenografts retained disease phenotypes and HPV DNA in the short term. Two laryngeal cancer cell lines were consistently HPV\u2010positive in multiple studies. Animal laryngeal infections with animal papillomaviruses resulted in disease and long\u2010term retention of viral DNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Laryngeal papillomavirus infection models have been researched for 100\u2009years and primarily involve low\u2010risk HPV. Most models lose viral DNA after a short duration. Future work is needed to model persistent and recurrent diseases, consistent with RRP and HPV\u2010positive laryngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 133:3256\u20133268, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30762","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T12:44:36Z","timestamp":1685018676000},"page":"3256-3268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preclinical Models of Laryngeal Papillomavirus Infection: A Scoping Review"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-3834","authenticated-orcid":false,"given":"Renee E.","family":"King","sequence":"first","affiliation":[{"name":"McArdle Laboratory for Cancer Research, Department of Oncology University of Wisconsin\u2010Madison  Madison Wisconsin 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