{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:02:18Z","timestamp":1789646538568,"version":"4.0.0"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Syphilis is an infectious disease caused by the spirochete Treponema pallidum. Rates have been rising in the US and globally. Known as the \u201cGreat Imitator,\u201d syphilis can involve head and neck subsites, and often can masquerade as possible carcinoma of the head and neck. Here, we present three distinct cases of syphilis presenting as suspected head and neck malignancy involving the oropharynx, larynx and oral cavity. All cases were diagnosed on surgical pathologic examination of diseased tissues and treated. It is important for practicing otolaryngologists to understand head and neck manifestations of syphilis to facilitate proper diagnosis and treatment. <jats:italic>Laryngoscope<\/jats:italic>, 134:236\u2013239, 2024<\/jats:p>","DOI":"10.1002\/lary.30765","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:31:35Z","timestamp":1685356295000},"page":"236-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Increasing Problem of Syphilis Manifesting as Head and Neck Cancer: A Case Series"],"prefix":"10.1002","volume":"134","author":[{"given":"August A.","family":"Culbert","sequence":"first","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine Case Western Reserve University  Cleveland Ohio U.S.A."},{"name":"Center for Immunotherapy and Precision Immuno\u2010Oncology Cleveland Clinic Lerner Research Institute  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Karoline","family":"Israel","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Ku","sequence":"additional","affiliation":[{"name":"Head and Neck Institute Cleveland Clinic  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie L.","family":"Silver","sequence":"additional","affiliation":[{"name":"Center for Immunotherapy and Precision Immuno\u2010Oncology Cleveland Clinic Lerner Research Institute  Cleveland Ohio U.S.A."},{"name":"Head and Neck Institute Cleveland Clinic  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Sexually Transmitted Disease Surveillance Centers for Disease Control and Prevention (CDC) National Overview Published April 11 2022. Accessed November 13 2022.https:\/\/www.cdc.gov\/std\/statistics\/2020\/overview.htm."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.73"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2018.1526559"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-018-0138-z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10111364"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T12:58:49Z","timestamp":1719925129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.30765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,29]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/lary.30765"],"URL":"https:\/\/doi.org\/10.1002\/lary.30765","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,29]]},"assertion":[{"value":"2022-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}