{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:26:19Z","timestamp":1791386779807,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R37AI71106"],"award-info":[{"award-number":["R37AI71106"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001109","name":"Flinn Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,1]]},"abstract":"\n Objective<\/jats:title>\n To evaluate eosinophil peroxidase (EPX) as a biomarker for tissue levels of eosinophilia, cytokines, and chemokines within chronic rhinosinusitis (CRS).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Twenty\u2010eight subjects undergoing sinonasal surgery were prospectively enrolled. Ethmoid tissue was analyzed with an in\u2010house EPX immunoassay and a 48\u2010plex cytokine\u2010chemokine array. Clinical severity was assessed using SNOT\u201022 and Lund\u2010Mackay scores. Subjects were grouped as follows: controls, polyp status (CRS with [CRSwNP] and without nasal polyps [CRSsNP]), tissue eosinophilia (eosinophilic CRS [eCRS], non\u2010eosinophilic CRS [neCRS]), or combinations thereof (eCRSwNP, eCRSsNP, neCRSsNP). eCRS was defined as >10 eosinophils per high power field (HPF). Subjects without CRS or asthma were enrolled as controls.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n EPX was elevated in CRSwNP compared to control (\n p<\/jats:italic>\n \u2009=\u20090.007), in eCRS compared to neCRS (\n p<\/jats:italic>\n \u2009=\u20090.002), and in eCRSwNP along with eCRSsNP compared to neCRSsNP (\n p<\/jats:italic>\n \u2009=\u20090.023,\n p<\/jats:italic>\n \u2009=\u20090.015, respectively). eCRS displayed elevated IL\u20105 compared to neCRS (\n p<\/jats:italic>\n \u2009=\u20090.005). No significant differences in EPX or IL\u20105 were observed between eCRSwNP and eCRSsNP. IL\u20105 was elevated in eCRSwNP (\n p<\/jats:italic>\n \u2009=\u20090.019) compared neCRSsNP. Area under the receiver operator characteristic curve was 0.938 (95% CI, 0.835\u20131.00) for EPX and tissue eosinophilia, with an optimal cut\u2010point of 470\u2009ng\/mL being 100% specific and 81.25% sensitive for tissue eosinophilia. Linear regression revealed a strong correlation between EPX and IL\u20105 (R\n 2<\/jats:sup>\n \u2009=\u20090.64,\n p<\/jats:italic>\n \u2009<\u20090.001). Comparing EPX and IL\u20105, only EPX displayed significant correlation with SNOT\u201022 (\n p<\/jats:italic>\n \u2009=\u20090.04) and Lund\u2010Mackay score (\n p<\/jats:italic>\n \u2009=\u20090.004).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n EPX is associated with tissue eosinophilia in CRS patients regardless of polyp status. EPX correlates with IL\u20105 and could be potentially considered a biomarker for anti\u2010IL\u20105 therapies.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n \n 3\n Laryngoscope<\/jats:italic>\n , 134:69\u201378, 2024\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.30787","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T07:34:03Z","timestamp":1685518443000},"page":"69-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Eosinophil Peroxidase: A Biomarker for Eosinophilic Chronic Rhinosinusitis Agnostic of Polyp Status"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4895-2185","authenticated-orcid":false,"given":"Beau M.","family":"Idler","sequence":"first","affiliation":[{"name":"Mayo Clinic Alix School of Medicine Mayo Clinic Arizona Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Iijima","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Clinical Immunology Mayo Clinic Arizona Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei I.","family":"Ochkur","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Clinical Immunology Mayo Clinic Arizona Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Clinical Immunology Mayo Clinic Arizona Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Rank","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Clinical Immunology Mayo Clinic Arizona Scottsdale Arizona USA"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Mayo Clinic Arizona Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Kita","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Clinical Immunology Mayo Clinic Arizona Scottsdale Arizona USA"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Mayo Clinic Arizona Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-2385","authenticated-orcid":false,"given":"Devyani","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Mayo Clinic Arizona Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"issue":"29","key":"e_1_2_8_2_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens WJ","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.11.037"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-019-0350-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1324"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13411"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.05.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.04.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892418779451"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22194"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2021.13.1.8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22781"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22083"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26604"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21994"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22101"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22264"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21032"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.512"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.938691"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000602"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.5.449"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.63.6.715"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7340"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.03.049"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.01.038"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2012.06.011"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21904"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.21.3.f160"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95693"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.3.400"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v22.i2.10"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.3.1764"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0502243"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011450"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.08.002"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01727.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170277"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxy061"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14892"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.031"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/75.5.693"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12817"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.020"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22632"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2022.04.004"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.02.017"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-00910-y"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T08:56:25Z","timestamp":1719910585000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.30787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,31]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/lary.30787"],"URL":"https:\/\/doi.org\/10.1002\/lary.30787","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,31]]},"assertion":[{"value":"2022-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}