{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:18:57Z","timestamp":1784996337293,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>\u201cDepth of invasion\u201d is an additional index incorporated in 8th AJCC staging system for oral cavity squamous cell carcinoma based on its prognostic significance. Pre\u2010operative assessment by clinical palpation and imaging modalities has been used with limitations. The aim of the study is to compare different techniques including clinical palpation, ultrasound, and magnetic resonance imaging with histopathology for assessment of depth of tumor invasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials<\/jats:title><jats:p>Fifty patients of carcinoma tongue (T1\u2013T3) were enrolled. Clinical palpation, Ultrasound tongue, and Magnetic resonance imaging were used to assess depth of tumor invasion. Microscopic depth of invasion was considered as reference. Statistical analysis was done to assess the level of agreement, reliability, and internal consistency. ROC analysis was done to find the \u201cArea Under Curve\u201d for microscopic depth versus ultrasound, MRI, and gross histopathological \u201cdepth of invasion\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ultrasound tongue showed highest \u201carea under curve\u201d, Intra class correlation (ICC:0.786) with a good consistency (Cronbach's Alpha:0.880) with histological reference compared to MRI(ICC:0.689;CA:0.816). Clinical palpation showed weak agreement (Kappa:0.43) for assessing depth. To observe the concordance between ultrasound and microscopic depth, Lin's Concordance Correlation Coefficient (CCC\u2009=\u20090.782) was calculated with 95% limits of agreement. Lin's concordance correlation between ultrasound and microscopic depth showed a good agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ultrasound tongue is a reliable imaging modality for pre\u2010operative T staging by assessing tumor \u201cdepth of invasion\u201d in carcinoma tongue patients with good internal consistency as per 8th AJCC staging system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2 (CEBM\u2010Level of Evidence\u20102.1) <jats:italic>Laryngoscope<\/jats:italic>, 134:215\u2013221, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30791","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T11:38:25Z","timestamp":1685446705000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Depth of Invasion in Carcinoma Tongue: Evaluation of Clinical and Imaging Techniques"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-0428","authenticated-orcid":false,"given":"Rajeev","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ponneth","family":"Sherif","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Manchanda","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adarsh","family":"Barwad","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5590-9279","authenticated-orcid":false,"given":"Prem","family":"Sagar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroof Ahmad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashu Seith","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-8093","authenticated-orcid":false,"given":"Chirom Amit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head Neck Surgery All India Institute of Medical Sciences  New Delhi 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