{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:32:27Z","timestamp":1747150347594,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the association between diabetes and outcomes in thyroidectomy patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort analysis used the 2015\u20132017 American College of Surgeons National Surgery Quality Improvement Program database. Current Procedural Terminology (CPT) codes were used to identify thyroidectomy cases (60210, 60212, 60220, 60225, 60240, 60252, 60254, 60260, 60270, and 60271). Demographics, comorbidities, and complication incidences were compared between diabetic and nondiabetic patients using Pearson's chi\u2010square test\/Fisher's exact test as appropriate. The independent effect of diabetes on outcomes was analyzed using binary logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 47,776 (95.4%) nondiabetic and 2307 (4.6%) diabetic patients undergoing thyroidectomy were identified from 2015 to 2017. Chi\u2010square analysis demonstrated that diabetic patients had higher incidences of obesity (55.2% vs. 33.2%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), dyspnea (12.7% vs. 4.8%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), poor functional status (1.9% vs. 0.4%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), ventilator dependence (0.6% vs. 0.1%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), chronic obstructive pulmonary disease (COPD; 6.8% vs. 2.2%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), congestive heart failure (1.1% vs. 0.3%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), acute renal failure (0.3% vs. 0.0%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), hypertension (79.2% vs. 32.4%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), dialysis (2.0% vs. 0.4%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), open wound (1.1% vs. 0.1%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), steroid use (5.3% vs. 2.3%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), bleeding disorders (3.6% vs. 0.9%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), preoperative blood transfusions (0.2% vs. 0.0%; <jats:italic>p<\/jats:italic>\u2009=\u20090.001), and systemic sepsis (1.0% vs. 0.3%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Demographic characteristics were significantly different between the cohorts including gender (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), age (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), race (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and Hispanic ethnicity (<jats:italic>p<\/jats:italic>\u2009=\u20090.033). After adjusting for these factors, logistic regression analyses showed that diabetes was associated with acute renal failure (OR: 5.836; 95% CI: 1.060\u201332.134; <jats:italic>p<\/jats:italic>\u2009=\u20090.043), wound disruption (OR: 6.194; 95% CI: 1.752\u201321.900; <jats:italic>p<\/jats:italic>\u2009=\u20090.005), prolonged length of stay (OR: 1.430; 95% CI: 1.261\u20131.622; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), unplanned readmission (OR: 1.380; 95% CI: 1.096\u20131.737; <jats:italic>p<\/jats:italic>\u2009=\u20090.006), superficial incisional surgical site infections (OR: 0.240; 95% CI: 0.058\u20130.995; <jats:italic>p<\/jats:italic>\u2009=\u20090.049), urinary tract infection occurrences (OR: 2.173; 95% CI: 1.186\u20133.980; <jats:italic>p<\/jats:italic>\u2009=\u20090.012), organ space surgical site infection occurrences (OR: 3.322; 95% CI: 1.016\u201310.864; <jats:italic>p<\/jats:italic>\u2009=\u20090.047), pneumonia occurrences (OR: 2.091; 95% CI: 1.125\u20133.884; <jats:italic>p<\/jats:italic>\u2009=\u20090.020), any medical complication (OR: 1.697; 95% CI: 1.246\u20132.313; <jats:italic>p<\/jats:italic>\u2009=\u20090.001), and any complication (OR: 1.495; 95% CI: 1.136\u20131.968; <jats:italic>p<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diabetes mellitus is a significant factor associated with increased odds of complications following thyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 133:3628\u20133632, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30902","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T10:19:43Z","timestamp":1689848383000},"page":"3628-3632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Diabetes on Morbidity and Mortality Following Thyroidectomy"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6691-3131","authenticated-orcid":false,"given":"Roshan V.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6804-6062","authenticated-orcid":false,"given":"Avneet","family":"Randhawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0013-9040","authenticated-orcid":false,"given":"Karandeep S.","family":"Randhawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-3956","authenticated-orcid":false,"given":"Owais M.","family":"Aftab","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4148-119X","authenticated-orcid":false,"given":"Imran M.","family":"Khawaja","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hegazin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-7818","authenticated-orcid":false,"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."},{"name":"Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark New Jersey U.S.A."},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School  Newark New Jersey U.S.A."},{"name":"Department of Ophthalmology and Visual Science Rutgers New Jersey Medical School  Newark New Jersey U.S.A."},{"name":"Department of Otolaryngology and Facial Plastic Surgery Saint Barnabas Medical Center\u2014RWJ Barnabas Health  Livingston New Jersey U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-2788","authenticated-orcid":false,"given":"Christina H.","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Albert Einstein College of Medicine  Bronx New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Statistics About 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