{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:12:10Z","timestamp":1781968330395,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>With widespread vaccination against COVID\u201019, concerns regarding side effects have been raised. We aim to assess the frequency of otolaryngologic adverse events (AEs) following COVID\u201019 vaccination as compared with other vaccines in a national database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective analysis of national registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Food and Drug Administration's Vaccine Adverse Event Reporting System (VAERS) database was queried from December 2020 to May 2021 for all COVID\u201019 vaccination AEs. Complaints were categorized as otolaryngologic and sub stratified into different anatomic components. Reporting odds ratios (ROR) and proportional reporting ratios (PRR) were determined for AEs of clinical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total number of AEs reported from vaccination with the Moderna, Pfizer\u2010BioNTech, and Janssen vaccines equaled 1,280,950. Of these, 62,660 (4.9%) were otolaryngologic in nature, with 32.6% associated with the oropharynx\/larynx, 18.3% with the nasal cavity\/sinuses, 17.1% with the ears\/vestibular system, 10.0% with the oral cavity, and 21.9% miscellaneous. Signal ratios reached significance levels for dysgeusia (<jats:italic>n<\/jats:italic>\u2009=\u20092124, PRR: 17.33, ROR: 16.36), ageusia (<jats:italic>n<\/jats:italic>\u2009=\u20091376, PRR: 2.81, ROR: 2.81), anosmia (<jats:italic>n<\/jats:italic>\u2009=\u2009983, PRR: 4.01, ROR: 4.01), rhinorrhea (<jats:italic>n<\/jats:italic>\u2009=\u20092203, PRR: 2.99, ROR: 3.00), throat tightness (<jats:italic>n<\/jats:italic>\u2009=\u20093666, PRR: 4.99, ROR: 5.00), throat irritation (<jats:italic>n<\/jats:italic>\u2009=\u20093313, PRR: 4.51, ROR: 4.52), dysphagia (<jats:italic>n<\/jats:italic>\u2009=\u20092538, PRR: 2.07, ROR: 2.07), tinnitus (<jats:italic>n<\/jats:italic>\u2009=\u20094377, PRR: 3.97, ROR: 3.98), and vertigo (<jats:italic>n<\/jats:italic>\u2009=\u20092887, PRR: 3.93, ROR: 3.93). Signal ratios were not significant for facial paralysis, Bell's palsy, anaphylaxis, sinusitis, hearing disability, and ear pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although several otolaryngologic symptoms were reported, few were found to be clinically significant. Of note, facial paralysis, Bell's palsy, and anaphylaxis did not meet signal thresholds to be determined significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 134:1163\u20131168, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30923","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T13:12:16Z","timestamp":1691154736000},"page":"1163-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Otolaryngologic Side Effects After <scp>COVID<\/scp>\u201019 Vaccination"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9081-2832","authenticated-orcid":false,"given":"Salma","family":"Ahsanuddin","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Albert Einstein College of Medicine, Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6244-8175","authenticated-orcid":false,"given":"Ryan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8926-7662","authenticated-orcid":false,"given":"Aatin K.","family":"Dhanda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-5036","authenticated-orcid":false,"given":"Kirolos","family":"Georges","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-7818","authenticated-orcid":false,"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Department of Ophthalmology and Visual Science Rutgers New Jersey Medical School  Newark New Jersey USA"},{"name":"Department of Otolaryngology and Facial Plastic Surgery Saint Barnabas Medical Center, RWJBarnabas Health  Livingston New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-2788","authenticated-orcid":false,"given":"Christina H.","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Albert Einstein College of Medicine, Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"National Academies of Sciences Engineering and Medicine.National Academies Release Framework for Equitable Allocation of a COVID\u201019 Vaccine for Adoption by HHS State Tribal Local and Territorial Authorities. 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