{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:48:41Z","timestamp":1754110121885,"version":"3.40.5"},"reference-count":67,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["T32DC000022"],"award-info":[{"award-number":["T32DC000022"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare taste changes after transoral robotic surgery (TORS) to taste changes in healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Oropharyngeal cancer patients receiving TORS and healthy controls were recruited. Participants underwent posterolateral and whole\u2010mouth psychophysical taste testing (identification, intensity, and hedonics) at baseline and at 2\u2009weeks postoperatively (patients) or follow\u2010up (controls). Surgeons reported suspension time and glossopharyngeal nerve injury (GNI) based on the identification and sacrifice of the nerve. A Clinical Global Impression (CGI) of taste symptoms was completed at each session (\u201cMy sense of taste bothers me\u201d on a 5\u2010point scale from Never [1] to Always [5]). A taste disorder (TD) was a CGI of 3 (Sometimes) or worse. Within\u2010subject changes in CGI and psychophysical scores were computed. \u201cWorsened taste\u201d was a CGI increase by \u22651 point at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 69 participants, most (33\/37 tumor, 31\/32 controls) had normal baseline taste (CGI\u2009&lt;\u20093). 14\/33 (42%) TORS patients and no controls developed new TDs at follow\u2010up. More smokers (7\/9) had worsened taste than nonsmokers (19\/60, difference\u2009=\u200946% [95% CI 16%\u201376%]). More patients without GNI (6\/22) than with GNI (0\/15) had postoperative phantogeusia (difference\u2009=\u200927% [95% CI 9\u201345%]). Tumor\u2010ipsilateral taste identification (TI) decreased more in patients (\u221211.3%) than controls (0.8%, difference\u2009=\u200912.2% [95% CI 5.0\u201319.3%]). Suspension time was not associated with worsened taste symptoms or psychophysical changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patient\u2010reported taste changes after TORS are frequent. Compared to healthy controls, TORS patients have decreased tumor\u2010ipsilateral TI. Suspension time and GNI are unlikely to cause symptomatic TDs. Further investigations of the etiology and long\u2010term symptom burden of TORS\u2010associated TDs will aid in the management of oropharyngeal cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 (non\u2010randomized controlled cohort study) <jats:italic>Laryngoscope<\/jats:italic>, 133:3520\u20133528, 2023<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30939","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T11:49:57Z","timestamp":1691495397000},"page":"3520-3528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute Taste Dysfunction in Oropharyngeal Cancer Patients after Transoral Robotic Surgery"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-2343","authenticated-orcid":false,"given":"Theresa","family":"Tharakan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorina","family":"Kallogjeri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Washington University School of Medicine  St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0631-0144","authenticated-orcid":false,"given":"Randall","family":"Paniello","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Washington University School of Medicine  St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3543-889X","authenticated-orcid":false,"given":"Sidharth V.","family":"Puram","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Washington University School of Medicine  St Louis Missouri USA"},{"name":"Department of Genetics Washington University School of Medicine  St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan S.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Washington University School of Medicine  St Louis Missouri 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