{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:25:36Z","timestamp":1784258736374,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Sentinel node biopsy (SNB) is a surgical staging test in which sentinel nodes (SNs) undergo intensive histological analysis. SNB diagnoses early cancer spread, but can also reveal unexpected findings within the SNs. We review cases of incidental thyroid cells (TC) found in SNs from patients with oral squamous cell carcinoma (OSCC) to assess the prevalence of TC, and the clinical significance of these.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicenter retrospective review of SNB performed for cT1\u2010T2N0 OSCC. Incidental TC were identified by TTF\u20101 or thyroglobulin positivity. Anatomical location of nodes containing TC, TC morphology, and ongoing management\/follow up of this incidental finding was recorded. Neck dissections performed during the same period were reviewed to establish the expected incidence of TC in neck nodes without serial sectioning analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>278 SNB cases were reviewed. Ten procedures detected TC in nine patients (10\/278, 3.6%). During the same time period 725 neck dissections were performed, six containing TCs (6\/725, 0.8%). One patient underwent SNB twice with TC identified on both occasions. Three patients had both OSCC metastasis and thyroid cells. All SNB patients with TC identified underwent thyroid USS with no primary tumours identified. Three patients underwent thyroidectomy, in all cases no primary thyroid tumour was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prevalence of incidental TC in SNs appears to be higher than that reported in neck dissections, these are not likely to be clinically relevant and can be managed on a conservative basis in the absence of clear metastatic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Multicentre retrospective cohort study, 3 <jats:italic>Laryngoscope<\/jats:italic>, 134:1278\u20131281, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.30996","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T13:18:34Z","timestamp":1692796714000},"page":"1278-1281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Incidental Thyroid Tissue in Sentinel Nodes From Oral Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-1270","authenticated-orcid":false,"given":"Clare","family":"Schilling","sequence":"first","affiliation":[{"name":"Head and Neck Academic Centre, University College London  London UK"},{"name":"Head &amp; Neck Surgery, University College London Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette","family":"Collins","sequence":"additional","affiliation":[{"name":"Head and Neck Pathology, Guy's &amp; St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Farrow","sequence":"additional","affiliation":[{"name":"Head &amp; Neck Surgery, University College London Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"McGurk","sequence":"additional","affiliation":[{"name":"Head and Neck Academic Centre, University College London  London UK"},{"name":"Head &amp; Neck Surgery, University College London Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Bisase","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Queen Victoria Hospital NHS Foundation Trust  East Grinstead UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Kerawala","sequence":"additional","affiliation":[{"name":"Head and Neck Unit Royal Marsden Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Wan","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine, UCLH NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Hall","sequence":"additional","affiliation":[{"name":"Head and Neck Pathology, Guy's &amp; St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-7422","authenticated-orcid":false,"given":"Selvam","family":"Thavaraj","sequence":"additional","affiliation":[{"name":"Head and Neck Pathology, Guy's &amp; St Thomas' NHS Foundation Trust  London UK"},{"name":"Faculty of Dentistry, Oral &amp; Craniofacial Science King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3786-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10304"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdip.2007.06.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896912449042"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000157841.63283.87"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1105653"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060761"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13291"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196605000-00002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1967)20:1<103::AID-CNCR2820200116>3.0.CO;2-S"},{"issue":"3","key":"e_1_2_6_12_1","first-page":"172","article-title":"Primary papillary thyroid carcinoma presenting as cervical lymphadenopathy: the operative approach to the \"lateral aberrant thyroid\"","volume":"59","author":"De Jong SA","year":"1993","journal-title":"Am Surg"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.05.013"},{"key":"e_1_2_6_14_1","first-page":"633","article-title":"Thyroid follicle inclusions IN cervical lymph nodes","volume":"77","author":"Gerard\u2010Marchant R","year":"1964","journal-title":"Arch Pathol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30115-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1416-7"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.30996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T12:36:07Z","timestamp":1708086967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.30996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,23]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/lary.30996"],"URL":"https:\/\/doi.org\/10.1002\/lary.30996","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,23]]},"assertion":[{"value":"2023-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}