{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:55:43Z","timestamp":1791377743739,"version":"4.3.2"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["IRG\u201019\u2010230\u201048\u2010IRG"],"award-info":[{"award-number":["IRG\u201019\u2010230\u201048\u2010IRG"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA023100"],"award-info":[{"award-number":["P30CA023100"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2KL2TR0014"],"award-info":[{"award-number":["2KL2TR0014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>With the shift toward utilization of sentinel lymph node biopsy (SLNB) in oral cavity cancer, improved techniques for intraoperative sentinel node identification are needed. This study investigates the feasibility of fluorescently labeled tilmanoscept in SLNB in an oral cancer rabbit model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An animal study was designed using 21 healthy male New Zealand rabbits. Gallium\u201068\u2010labeled tilmanocept labeled with IRDye800CW was injected submucosally into the buccal mucosa (<jats:italic>n<\/jats:italic>\u2009=\u20096) or lateral tongue (<jats:italic>n<\/jats:italic>\u2009=\u20097) followed by PET imaging. One hour after injection, SLNB was performed using fluorescence imaging followed by a bilateral neck dissection and sampling of non\u2010nodal surrounding tissue. All tissues were measured for radioactivity and fluorescence. In addition, eight rabbits were injected with delayed SLNB performed 48\u2009h after injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Buccal injections all had ipsilateral SLN drainage and tongue injections exhibited 18.2% contralateral drainage. An average of 1.9\u2009\u00b1\u20091.0 SLN (range 1\u20135) were identified. In addition, an average of 16.9\u2009\u00b1\u20093.3 non\u2010sentinel lymph nodes were removed per animal. SLNs had an average of 0.69\u2009\u00b1\u20090.60 percent\u2010of\u2010injected dose (%ID) compared with non\u2010sentinel nodes with 0.012\u2009\u00b1\u20090.025 %ID and surrounding tissue with 0.0067\u2009\u00b1\u20090.015 %ID. There was 98.0% agreement between sentinel lymph nodes identified using fluorescence compared to radioactivity with Cohen's kappa coefficient of 0.879. In 48\u2010h delayed SLNB, results were consistent with 97.8% agreement with radioactivity and Cohen's Kappa coefficient of 0.884. Fluorescence identified additional lymph nodes that were not identified by radioactivity, and with one false negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fluorescent\u2010labeled Tc\u201099\u2009m\u2010tilmanocept represents a highly accurate adjunct to enhance SLNB for oral cavity cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>N\/A <jats:italic>Laryngoscope<\/jats:italic>, 134:1299\u20131307, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31014","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:45:21Z","timestamp":1693917921000},"page":"1299-1307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fluorescent Guided Sentinel Lymph Mapping of the Oral Cavity with Fluorescent\u2010Labeled Tilmanocept"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1689-3275","authenticated-orcid":false,"given":"Theresa","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University of California, San Diego  La Jolla California U.S.A."},{"name":"Moores Cancer Center University of California, San Diego  La Jolla California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie S.","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University of California, San Diego  La Jolla California U.S.A."},{"name":"Moores Cancer Center University of California, San Diego  La Jolla California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Moores Cancer Center University of California, San Diego  La Jolla California U.S.A."},{"name":"Department of Radiology University of California, San Diego  La Jolla California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University of California, San Diego  La Jolla California U.S.A."},{"name":"Moores Cancer Center University of California, San Diego  La Jolla California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Ashworth","sequence":"additional","affiliation":[{"name":"Moores Cancer Center University of California, San Diego  La Jolla California U.S.A."},{"name":"Department of Radiology University of California, San Diego  La Jolla California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher V.","family":"Barback","sequence":"additional","affiliation":[{"name":"Moores Cancer Center University of California, San Diego  La Jolla California U.S.A."},{"name":"Department of Radiology University of California, San Diego  La Jolla California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hall","sequence":"additional","affiliation":[{"name":"Moores Cancer Center University of California, San Diego  La Jolla California U.S.A."},{"name":"Department of Radiology University of California, San Diego  La Jolla California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Vera","sequence":"additional","affiliation":[{"name":"Moores Cancer Center University of California, San Diego  La Jolla California U.S.A."},{"name":"Department of Radiology University of California, San Diego  La Jolla California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2009.08.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.08.023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.01.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.01661"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.03637"},{"key":"e_1_2_7_9_1","unstructured":"LaiSY.Comparing sentinel lymph node (SLN) biopsy with standard neck dissection for patients with early\u2010stage Oral cavity cancer. 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