{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:18:40Z","timestamp":1791238720861,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This review aims to quantify the pooled functional gain (FG) in different types of hearing loss with the transcutaneous hearing device, Osia (Cochlear, Sydney, Australia) in comparison with the unaided state. Secondary outcomes are patient\u2010reported outcomes measures (PROMs) and complication rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Medline, Embase, SCOPUS, Cochrane CENTRAL, PROSPERO and Cochrane Library.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Systematic review and meta\u2010analysis of indexed search terms relating to \u201cOsia,\u201d \u201cOsseointegration,\u201d \u201cCochlear Implant,\u201d and \u201cBone\u2010Anchored Prosthesis\u201d was performed from database inception to September 20, 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 168 studies identified, 14 studies with 15 patient cohorts (<jats:italic>n<\/jats:italic>\u2009=\u2009314) met inclusion criteria for meta\u2010analysis. Pooled overall mean FG for all types of hearing loss was 35.0\u2009dB sound pressure level (SPL) (95% confidence interval [CI] 29.12\u201340.97) compared against unaided hearing. Pooled FG for conductive\/mixed hearing loss was 37.7\u2009dB SPL (95% CI 26.1\u201349.3). Pooled single\u2010sided deafness (SSD) FG could not be calculated due to the small patient cohort for whom SSD data was reported. There is a trend toward improvements in speech receptiveness threshold, signal to noise ratio, and some PROMs compared with baseline hearing. Early complication rates demonstrate risks similar to other transcutaneous implants, with a low predicted explantation (0.11%, 95% CI 0.00%\u20131.90%) and wound infection rate (1.92% [95% CI 0.00%\u20136.17%]). No articles directly comparing transcutaneous devices were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Osia devices demonstrate clear audiologic benefits and a good safety profile for the included patient population. Our study results indicate that frequency\u2010specific gain, PROMs, and the audiological benefit in single\u2010sided deafness may be areas for future prospective research. <jats:italic>Laryngoscope<\/jats:italic>, 134:1531\u20131539, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31053","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T10:55:17Z","timestamp":1695034517000},"page":"1531-1539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Systematic Review and Meta\u2010Analysis of a New Active Transcutaneous Bone Conduction Implant"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-5986","authenticated-orcid":false,"given":"Seraphina","family":"Key","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nusrat","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Canterbury Hospital  Campsie New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melville","family":"Da Cruz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Camperdown New South Wales Australia"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery John Hunter Hospital  New Lambton Heights New South Wales Australia"},{"name":"School of Medicine and Public Health The University of Newcastle  Callaghan New South Wales Australia"},{"name":"Faculty of Medicine Macquarie University  Macquarie Park New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-578X","authenticated-orcid":false,"given":"Zubair","family":"Hasan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Camperdown New South Wales Australia"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery John Hunter Hospital  New Lambton Heights New South Wales Australia"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery The Royal Children's Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221484"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12484"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29892"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/audiolres11020019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2019.1691744"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-020-00454-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215122001839"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003590"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0000000000002794"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1742352"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0014.9342"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102818"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_7_17_1","unstructured":"Veritas Health I.Covidence Systematic Review Software Melbourne Australia.2020."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_7_19_1","volume-title":"Joanna Briggs Institute Reviewer's Manual","author":"Moola S","year":"2017"},{"key":"e_1_2_7_20_1","volume-title":"Joanna Briggs Institute Reviewer's Manual","author":"Moola S","year":"2017"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411"},{"key":"e_1_2_7_22_1","unstructured":"OCEBM Levels of Evidence Working Group.The Oxford 2011 Levels of Evidence. 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