{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:46:05Z","timestamp":1789832765102,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Studies examining electromyography (EMG)\u2010guided laryngeal onobotulinumtoxinA (BTxA) injection for chronic cough reveal promising efficacy, however, are limited by small cohorts and absent quantifiable outcomes. It further remains unclear if pulmonary disease limits efficacy, or if vagal motor neuropathy prognosticates response. We hypothesize BTxA injection results in qualitative improvement in cough, decrease in Cough Severity Index (CSI), no change in Voice Handicap Index\u201010 (VHI\u201010), and complication rates comparable to historical data. We also examine the correlation of pulmonary comorbidities and vocal fold hypomobility with treatment efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Charts for patients receiving percutaneous adductor compartment BTxA injection for cough were reviewed for the binary outcome of patient\u2010reported presence or absence of improvement. Generalized estimating equations regression models were used to analyze the change in CSI (\u0394CSI) and the correlation of \u0394CSI with qualitative outcomes. Multivariable analyses were used to examine correlation of vocal fold hypomobility and pulmonary disease with qualitative outcomes and \u0394CSI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven patients underwent 197 BTxA injections from June 2012 to June 2022. A statistical proportion of 0.698 (0.599\u20130.813, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) or 69.8% of injections resulted in subjective improvement. Mean \u0394CSI was \u22122.12 (0.22\u20134.02, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), indicating overall improvement. With and without subjective improvement, estimated \u0394CSI was \u22124.43 and +2.68, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). VHI\u201010 did not change (0.69, <jats:italic>p<\/jats:italic>\u2009=\u20090.483). Neither pulmonary disease nor vocal fold hypomobility correlated with subjective improvement or \u0394CSI. Dysphagia occurred following 15 (7.6%) injections with no aspiration pneumonia or hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BTxA injection to the laryngeal adductors may effectively treat cough with limited risk for serious complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 134:1749\u20131756, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31072","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:13:01Z","timestamp":1695993181000},"page":"1749-1756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of Botulinum A Injection to the Laryngeal Adductor Compartment for Treatment of Cough"],"prefix":"10.1002","volume":"134","author":[{"given":"Brett A.","family":"Campbell","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Harvard Medical School  Boston Massachusetts U.S.A."},{"name":"Division of Otolaryngology, Department of Surgery Beth Israel Deaconess Medical Center  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria B.","family":"Flormann","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology, Department of Surgery Beth Israel Deaconess Medical Center  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger B.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Medicine Beth Israel Deaconess Medical Center  Boston Massachusetts U.S.A."},{"name":"Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-0534","authenticated-orcid":false,"given":"Pavan 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