{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T02:42:07Z","timestamp":1774406527108,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019M3E5D5064110"],"award-info":[{"award-number":["2019M3E5D5064110"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1F1A1066232"],"award-info":[{"award-number":["2022R1F1A1066232"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000209494"],"award-info":[{"award-number":["RS\u20102023\u201000209494"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objective<jats:bold>s<\/jats:bold><\/jats:title><jats:p>To conduct a systematic review and meta\u2010analysis of published articles to assess the impact of inferior turbinate\/meatus augmentation in patients diagnosed with empty nose syndrome (ENS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>PubMed, Cochrane database, Embase, Web of Science, SCOPUS, and Google Scholar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>Six databases were searched to December 2022. We retrieved studies evaluating improvements in refractory ENS\u2010related symptoms based on various patient\u2010reported outcome measures after inferior turbinate\/meatus augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As a result of meta\u2010analysis, Sinonasal Outcome Test, Empty Nose Syndrome 6\u2010Item Questionnaire (ENS6Q), and depression scores were measured at 1\u2009week; 1, 3, and 6\u2009months; and later than 12\u2009months after intervention for patients with ENS. All scores revealed significant symptom improvement. By reference to the minimal clinically important difference of the ENS6Q (6.25), inferior turbinate\/meatus augmentation relieved the nasal symptoms of ENS in the long term. Although the improvements in anxiety scores at 1\u2009week (0.4133 [\u22120.3366; 1.1633], 0.00, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009NA) and 1\u2009month (0.4525 [\u22120.0529; 0.9579], I<jats:sup>2<\/jats:sup>\u2009=\u20090.0%) were not statistically significant, the scores differed significantly at 3\u2009months (0.7351 [0.4143; 1.0559], <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200928.4%), 6\u2009months (0.8297 [0.6256; 1.0337], <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200937.2%), and longer than 12\u2009months (0.7969 [0.4768; 1.1170], <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data and analysis suggest that performing inferior turbinate\/meatus augmentation on ENS patients may improve not only nasal symptom scores but also accompanying psychological problems such as anxiety and depression. 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