{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:15:59Z","timestamp":1782450959213,"version":"3.54.5"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Salivary gland malignancies comprise a heterogeneous group of pathologies, for which treatment of the clinically negative neck may vary depending on numerous factors. Herein we present data on occult nodal metastases (ONM) as well as survival and recurrence from a large series of cN0 salivary gland malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review was conducted on 532 patients, with 389 patients with major salivary gland cancers and 143 patients with minor salivary gland cancers. Demographic and treatment data were included and rates of ONM, overall survival, local recurrence, regional recurrence, and distant recurrence were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the overall rate of ONM for parotid was 27% (63\/235), for submandibular\/sublingual was 35% (18\/52), and for minor was 15% (4\/26). Analysis of ONM rate at each nodal level was also performed, finding higher rates of level IV and V ONM than prior studies. Submandibular\/sublingual and minor salivary gland malignancies showed a predominance of ONMs at levels I\u2013III. Our survival and recurrence rates were similar to those found in previous studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data also demonstrate a predominance of ONM in levels I\u2013III for submandibular\/sublingual and minor salivary gland cancers, suggesting elective dissection in these levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 134:1705\u20131715, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31119","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T13:40:10Z","timestamp":1697550010000},"page":"1705-1715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Occult Nodal Metastases in Individuals with Clinically Node\u2010Negative Salivary Gland Malignancies"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4188-5063","authenticated-orcid":false,"given":"Emily S.","family":"Zhang","sequence":"first","affiliation":[{"name":"Head and Neck Institute Cleveland Clinic  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan B.","family":"Hair","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University Hospitals  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Lamarre","sequence":"additional","affiliation":[{"name":"Head and Neck Institute Cleveland Clinic  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo A.","family":"Koyfman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cleveland Clinic  Cleveland Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian B.","family":"Burkey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Cleveland Clinic Florida  Vero Beach Florida U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890080309"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13952"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23249"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21706"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920201)69:3<615::aid-cncr2820690303>3.0.co;2-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2019.1674143"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1663-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.10125"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.7.720"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.12.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.10.044"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2012.11.012"},{"key":"e_1_2_6_14_1","volume-title":"WHO Classification of Tumours. Pathology and Genetics of Head and Neck Tumours","author":"El\u2010Naggar A","year":"2017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.04.008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2012.03.009"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.2.96"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2017.03.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.018"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23467"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178099"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815594789"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(03)00105-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3681-y"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2020.08.026"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.029"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.02.004"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903062160"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13137"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24772"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26541"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2019.10.323"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.7.849"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23507"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5637-x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116009749"},{"issue":"3","key":"e_1_2_6_37_1","first-page":"191","article-title":"Results in the management of malignant submandibular tumours and guidelines for elective neck treatment","volume":"40","author":"Pohar S","year":"2011","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12458"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197301)31:1<117::aid-cncr2820310116>3.0.co;2-7"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(89)90004-5"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23711"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26172"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2022.03.001"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2019.102307"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2003.06.012"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24981"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05924-w"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2018.01.011"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32208"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199812)20:8<699::AID-HED7>3.0.CO;2-P"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21641"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28238"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T13:01:39Z","timestamp":1719925299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/lary.31119"],"URL":"https:\/\/doi.org\/10.1002\/lary.31119","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]},"assertion":[{"value":"2023-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}