{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:41:20Z","timestamp":1791301280470,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,5]]},"abstract":"\n Objective<\/jats:title>\n To assess the long\u2010term safety and effectiveness of temperature\u2010controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN), a minimally invasive treatment for chronic rhinitis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A prospective, single\u2010arm study of 129 patients at 16 centers (United States, Germany) was conducted. Patient\u2010reported outcome measures were the 24\u2010h reflective total nasal symptom score (rTNSS) and mini rhinoconjunctivitis quality of life questionnaire (MiniRQLQ). Postnasal drip and cough symptoms were assessed using a 4\u2010point scale.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean pretreatment rTNSS was 7.8 (95% CI, 7.5\u20138.1). The significant rTNSS treatment effect at 3\u2009months (\u22124.2 [95% CI, \u22124.6 to \u22123.8];\n p<\/jats:italic>\n \u2009<\u20090.001) was sustained through 2\u2009years (\u22124.5 [95% CI, \u22125.0 to \u22123.9];\n p<\/jats:italic>\n \u2009<\u20090.001), a 57.7% improvement. At 2\u2009years, the proportion of patients with a minimal clinically important difference (MCID) of \u226530% improvement in rTNSS from baseline was 80.0% (95% CI, 71.4%\u201386.5%). Individual postnasal drip and cough symptom scores were significantly improved from baseline through 2\u2009years. The proportion of patients who reached the MCID for the MiniRQLQ (\u22650.4\u2010point improvement) at 2\u2009years was 77.4% (95% CI, 68.5%\u201384.3%). Of 81 patients using chronic rhinitis medications at baseline, 61.7% either stopped all medication use (28.4%) or stopped or decreased (33.3%) use of \u22651 medication class at 2\u2009years. No device\/procedure\u2010related serious adverse events were reported throughout 2\u2009years.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n TCRF neurolysis of the PNN resulted in sustained improvements in chronic rhinitis symptom burden and quality of life through 2\u2009years, accompanied by a substantial decrease in medication burden.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n \n 4\n Laryngoscope<\/jats:italic>\n , 134:2077\u20132084, 2024\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.31120","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T09:03:28Z","timestamp":1698915808000},"page":"2077-2084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Two\u2010Year Outcomes After Radiofrequency Neurolysis of Posterior Nasal Nerve in Chronic Rhinitis"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-855X","authenticated-orcid":false,"given":"Jivianne T.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery UCLA David Geffen School of Medicine Los Angeles California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Advanced ENT and Allergy Louisville Kentucky U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Charous","sequence":"additional","affiliation":[{"name":"Arizona Desert Ear, Nose & Throat Specialists Goodyear Arizona U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Cuevas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6nder","family":"G\u00f6ktas","sequence":"additional","affiliation":[{"name":"ENT\u2010Center HNO\u2010Zentrum am Kudamm Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5785-183X","authenticated-orcid":false,"given":"Patricia A.","family":"Loftus","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of California San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan E.","family":"Nachlas","sequence":"additional","affiliation":[{"name":"ENT and Allergy Associates of Florida Boca Raton Florida U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina M.","family":"Toskala","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Thomas Jefferson University Philadelphia Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Fort Worth ENT Group Fort Worth Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5148-9342","authenticated-orcid":false,"given":"Detlef","family":"Brehmer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University Witten\/Herdecke Witten Germany"},{"name":"Department of Electrical Engineering and Applied Natural Sciences Westphalian University of Applied Sciences Gelsenkirchen Germany"},{"name":"Department of Otorhinolaryngology Private ENT Practice G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13991"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-021-03031-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otot.2007.05.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1907862"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211033400"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/21526575221096045"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X211041124"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23047"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2022.103776"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924221109987"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2003.00420.x"},{"key":"e_1_2_7_13_1","volume-title":"AHRQ 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