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Since this tumor is quite rare, most publications describe only small cohorts of patients. We aimed to investigate the clinical, pathological, and prognostic features of this newly defined malignant entity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Pubmed, Google Scholar, and Web of Science databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>All published articles between 2010 and 2023 were reviewed. Search terms included the terms \u201cMammary Analogue Secretory Carcinoma\u201d and \u201cSecretory Carcinoma\u201d. All articles published in English reporting on Secretory Carcinoma of salivary glands were retrieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred and 12 retrospective articles reporting a total of 674 patients were included, with 52% males and a mean age of 44.9\u2009\u00b1\u200918.9. The event rate for patients with advanced\u2010stage disease (Stage 3\/4) at presentation was 24.1% (95% CI 17.6%\u201331.9%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20099.2%), 14.6% for regional metastases (95% CI 10.5%\u201320%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200912%), and the event rate of distant metastasis was 8.4% (95% CI 5.5%\u201312.7%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20094.2%). Adjuvant radiotherapy was administered for 30.3% of patients (95% CI 24.1%\u201337.2%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200921.5%). The recurrence rate was 19% (95% CI 15.1%\u201323.8%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20095%). Survival outcomes showed a 17.2% death of disease rate for Secretory Carcinoma patients (95% CI 13.5%\u201321.8%, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20097.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Secretory Carcinoma is a rare and relatively newly defined entity arising in the parotid gland most commonly. Characterized as a low\u2010grade tumor, the majority of patients are diagnosed at an early stage, without regional or distant disease, and the prognosis is relatively good.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 134:1716\u20131724, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31123","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T12:55:06Z","timestamp":1698843306000},"page":"1716-1724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Salivary Gland Secretory Carcinoma; Review of 13\u2009Years World\u2010Wide Experience and Meta\u2010Analysis"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-9774","authenticated-orcid":false,"given":"Eyal","family":"Yosefof","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Rabin Medical Center\u2010Beilinson Hospital  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Boldes","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Rabin Medical Center\u2010Beilinson Hospital  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Rabin Medical Center\u2010Beilinson Hospital  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Robenshtok","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Institute of Endocrinology, Diabetes and Metabolism Rabin Medical Center  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Strenov","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Pathology Rabin Medical Center  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Bachar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Rabin Medical Center\u2010Beilinson Hospital  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Shpitzer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Rabin Medical Center\u2010Beilinson Hospital  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7462-1086","authenticated-orcid":false,"given":"Aviram","family":"Mizrachi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Rabin Medical Center\u2010Beilinson Hospital  Petach Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","unstructured":"SkalovaA VanecekT SimaR et al.Mammary analogue secretory carcinoma of salivary glands containing the ETV6\u2010NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.2010www.ajsp.com.","DOI":"10.1097\/PAS.0b013e3181d9efcc"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05604-4"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.03.017"},{"issue":"3","key":"e_1_2_5_5_1","first-page":"e123","article-title":"PRISMA group. 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