{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:51:52Z","timestamp":1792443112672,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this work was to gather an international consensus group to propose a global definition and diagnostic approach of laryngopharyngeal reflux (LPR) to guide primary care and specialist physicians in the management of LPR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010eight international experts (otolaryngologists, gastroenterologists, surgeons, and physiologists) were included in a modified Delphi process to revise 48 statements about definition, clinical presentation, and diagnostic approaches to LPR. Three voting rounds determined a consensus statement to be acceptable when 80% of experts agreed with a rating of at least 8\/10. Votes were anonymous and the analyses of voting rounds were performed by an independent statistician.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After the third round, 79.2% of statements (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200938\/48) were approved. LPR was defined as a disease of the upper aerodigestive tract resulting from the direct and\/or indirect effects of gastroduodenal content reflux, inducing morphological and\/or neurological changes in the upper aerodigestive tract. LPR is associated with recognized non\u2010specific laryngeal and extra\u2010laryngeal symptoms and signs that can be evaluated with validated patient\u2010reported outcome questionnaires and clinical instruments. The hypopharyngeal\u2013esophageal multichannel intraluminal impedance\u2013pH testing can suggest the diagnosis of LPR when there is &gt;1 acid, weakly acid or nonacid hypopharyngeal reflux event in 24\u2009h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A global consensus definition for LPR is presented to improve detection and diagnosis of the disease for otolaryngologists, pulmonologists, gastroenterologists, surgeons, and primary care practitioners. The approved statements are offered to improve collaborative research by adopting common and validated diagnostic approaches to LPR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      5\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 134:1614\u20131624, 2024\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.31134","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T07:04:22Z","timestamp":1699254262000},"page":"1614-1624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["The Dubai Definition and Diagnostic Criteria of Laryngopharyngeal Reflux: The\n                    <scp>IFOS<\/scp>\n                    Consensus"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU de Bruxelles, CHU Saint\u2010Pierre, School of Medicine  Brussels Belgium"},{"name":"Department of Laryngology and Broncho\u2010Esophagology (Anatomy Department), EpiCURA Hospital, UMONS Research Institute for Health Sciences and Technology University of Mons (UMons)  Mons Belgium"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Foch Hospital, Paris Saclay University, Research Committee of Young\u2010Otolaryngologists of the International Federations of Oto\u2010Rhino\u2010Laryngological Societies (YO\u2010IFOS)  Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Polyclinic of Poitiers  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Vaezi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-8230","authenticated-orcid":false,"given":"Walter W.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-7045","authenticated-orcid":false,"given":"Jacqueline E.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2488-5539","authenticated-orcid":false,"given":"Petros D.","family":"Karkos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Thessaloniki Medical School  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU de Bruxelles, CHU Saint\u2010Pierre, School of Medicine  Brussels Belgium"},{"name":"Department of Laryngology and Broncho\u2010Esophagology (Anatomy Department), EpiCURA Hospital, UMONS Research Institute for Health Sciences and Technology University of Mons (UMons)  Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6290-3331","authenticated-orcid":false,"given":"Kenneth W.","family":"Altman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Geisinger Medical Center  Danville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan R.","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery New York University School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareck","family":"Ayad","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head Neck Surgery Montreal Hospital  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R.","family":"Barillari","sequence":"additional","affiliation":[{"name":"Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine L. 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