{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T02:18:32Z","timestamp":1769998712817,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the accuracy of four\u2010dimensional computerized\u2010tomography (4DCT) for localizing parathyroid adenomas (PTAs) in cases with discordant or non\u2010localizing ultrasonography (US) and Technetium\u201099 sestamibi (MIBI) scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>Retrospective case series and systematic review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>A case series and meta\u2010analysis of patients diagnosed with primary hyperparathyroidism and discordant US and MIBI scans who underwent 4DCT prior to surgery. A comprehensive search for all relevant publications in the English literature between December 2006 and March 2022 was conducted for the meta\u2010analysis. Patients undergoing parathyroidectomy between January 2015 and December 2021 were identified from the institutional electronic database for the case series. All studies were analyzed for sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the 4DCT adenoma localization capabilities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen retrospective studies that included 379 patients and one case series that included 37 patients were identified and analyzed. A per\u2010patient analysis revealed sensitivity for lateralization to the correct side (<jats:italic>n\u2009=<\/jats:italic>\u2009181) ranging from 80% to 100% with a fixed effects model of 89% (95%confidence interval [CI]: 82%\u201393%) and a PPV for lateralization ranging from 63%\u201395% with a random effects model of 87% (95% CI: 77%\u201395%). Sensitivity of localization to the correct quadrant (<jats:italic>n\u2009=<\/jats:italic>\u2009172) ranged from 53% to 100% with a random effects model of 90.4% (95% CI: 76%\u201399%), and the PPV for localization ranged from 52% to 100% with a random effects model of 82% (95% CI: 73%\u201389%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>4DCT enhances imaging capabilities of localizing PTAs in cases of discordant or non\u2010localizing US and MIBI scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 134:2198\u20132205, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31142","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T11:59:51Z","timestamp":1699271991000},"page":"2198-2205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>4DCT<\/scp> in Discordant Parathyroid Adenoma Scans: Case Series and <scp>Meta\u2010Analysis<\/scp>"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-5291","authenticated-orcid":false,"given":"Anton","family":"Warshavsky","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head &amp; Neck Surgery and Maxillofacial Surgery and The Department of Radiology and Imaging, Metabolism and Hypertension Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raz","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head &amp; Neck Surgery and Maxillofacial Surgery and The Department of Radiology and Imaging, Metabolism and Hypertension Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0628-1942","authenticated-orcid":false,"given":"Narin Nard","family":"Carmel\u2010Neidermann","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head &amp; Neck Surgery and Maxillofacial Surgery and The Department of Radiology and Imaging, Metabolism and Hypertension Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Brenner","sequence":"additional","affiliation":[{"name":"Radiology and Imaging, School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genady","family":"Shendler","sequence":"additional","affiliation":[{"name":"Radiology and Imaging, School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-2088","authenticated-orcid":false,"given":"Liyona","family":"Kampel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head &amp; Neck Surgery and Maxillofacial Surgery and The Department of Radiology and Imaging, Metabolism and Hypertension Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Izkhakov","sequence":"additional","affiliation":[{"name":"The Institute of Endocrinology, School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidal","family":"Muhanna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head &amp; Neck Surgery and Maxillofacial Surgery and The Department of Radiology and Imaging, Metabolism and Hypertension Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilad","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head &amp; Neck Surgery and Maxillofacial Surgery and The Department of Radiology and Imaging, Metabolism and Hypertension Tel\u2010Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.10.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0565"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.05.029"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.08.029"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.09.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816655311"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4331-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6367-z"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815599372"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812458767"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2004.04.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1507-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199709000-00017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.12.1240"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817aecad"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10043"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12110852"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25781"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3940-y"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1870-5"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.2649"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12326"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.1671"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6115-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e31828beb34"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814562195"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3509-9"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.12571"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.11.010"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14374"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-4147-4"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0145561319828668"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2019.0182"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2019.01361"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2020.07.055"},{"key":"e_1_2_8_39_1","article-title":"A retrospective cohort study of the utility of ultrasound, 99mTc\u2010Sestamibi scintigraphy, and four\u2010dimensional computed tomography for pre\u2010operative localization of parathyroid disease to facilitate minimally invasive parathyroidectomy","volume":"14","author":"Hillyar CR","year":"2022","journal-title":"Cureus"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T10:50:56Z","timestamp":1721818256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,6]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/lary.31142"],"URL":"https:\/\/doi.org\/10.1002\/lary.31142","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,6]]},"assertion":[{"value":"2023-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}