{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:09:57Z","timestamp":1784005797137,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the long\u2010term control rates and hearing outcomes for growing vestibular schwannoma in <jats:italic>NF2<\/jats:italic>\u2010related schwannomatosis (NF2) treated with stereotactic radiosurgery (SRS) and fractionated radiotherapy (FRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of all patients treated with SRS\/FRT between 1986 and2021 from a tertiary NF2 unit. Overall tumor control was defined as: (1) growth control (growth failure was defined as growth in any dimension of 3 millimetres or more from baseline post\u2010SRS\/FRT), and (2) treatment control (no need for further intervention). Loss of serviceable hearing was defined as a drop in speech discrimination score below 50% after SRS\/FRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 81 cases, with a mean duration of follow\u2010up of 125\u2009months. Overall control rate was 72% (58\/81), with 80% (65\/81) growth control and 74% (60\/81) treatment control. There was a 5\u2010year actuarial survival of 77% and 10\u2010year survival of 71%. Forty\u2010three percent (30\/69) of cases did not have serviceable hearing at baseline. Of those remaining, 49% (19\/39) preserved serviceable hearing during follow\u2010up at a mean of 106\u2009months. Actuarial survival for preservation of serviceable hearing at 5 and 10\u2009years was 69% and 53%. There were poorer outcomes with increasing genetic severity, and with baseline tumor size &gt;3\u2009cm. No cases of SRS\/FRT\u2010related malignancy were identified at a mean follow\u2010up of 10\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Stereotactic radiosurgery\/fractionated radiotherapy are an effective option to treat growing vestibular schwannoma in patients with NF2 with the potential for hearing preservation in a proportion of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4\u2014Case Series <jats:italic>Laryngoscope<\/jats:italic>, 134:2364\u20132371, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31180","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:12:21Z","timestamp":1700565141000},"page":"2364-2371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Stereotactic Radiosurgery and Radiotherapy for Vestibular Schwannoma in <scp><i>NF2<\/i><\/scp>\u2010Related Schwannomatosis"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8457-7904","authenticated-orcid":false,"given":"Manu","family":"Shrivastava","sequence":"first","affiliation":[{"name":"Department of Ear, Nose and Throat Surgery Oxford University Hospitals  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Emmanouil","sequence":"additional","affiliation":[{"name":"NHS England Wellington House  London UK"},{"name":"Blizard Institute, Faculty of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Surgery Oxford University Hospitals  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Halliday","sequence":"additional","affiliation":[{"name":"Department of Genetics Oxford University Hospitals  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson","family":"Parry","sequence":"additional","affiliation":[{"name":"Department of Neurology Oxford University Hospitals  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Halliday","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Oxford University Hospitals  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Mackeith","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Surgery Oxford University Hospitals  Oxford 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