{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:21:51Z","timestamp":1787314911755,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071034"],"award-info":[{"award-number":["82071034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to investigate dynamic change of permeability of blood\u2010labyrinth barrier (BLB) after noise exposure and its effect on the drug delivery efficiency of systemic administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Gadopentetate dimeglumine (Gd\u2010DTPA) and dexamethasone (DEX) were used as tracers, and magnetic resonance imaging (MRI) and immunofluorescence were used to observe the change of the BLB after strong noise exposure in guinea pigs. High\u2010performance liquid chromatography\u2010mass spectrometry (LC\u2013MS) was used to observe the effect of the breakdown of BLB after noise exposure on the drug delivery efficiency of intravenous DEX. The guinea pigs were divided into 6 groups: normal group (N), 1, 3, 5, 8, and 12\u2009days after noise exposure groups (P1, P3, P5, P8, P12), with 5 animals in each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The BLB changes dynamically after noise exposure. Increased permeability of the blood\u2010endolymph barrier, the endolymph\u2010perilymph barrier, and the blood\u2010nerve barrier was observed at days 1\u20133, 1\u20135, and 1\u20138, respectively, after noise exposure in guinea pigs. Higher drug concentration in the cochlear tissue was obtained by intravenous administration of DEX in guinea pigs during the time window of increased permeability of the BLB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After noise exposure, the increased BLB permeability makes it easier for drugs to enter the inner ear from blood. In guinea pigs, 1\u20138\u2009days after strong noise exposure, the drug delivery efficiency of systemic administration increased. After 8\u2009days, the efficiency gradually returned to normal level. 1\u20138\u2009days after noise exposure may be the best intervention time for systemic administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      NA\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 134:2377\u20132386, 2024\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.31194","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T14:20:03Z","timestamp":1700662803000},"page":"2377-2386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Breakdown of Blood\u2010Labyrinth Barrier Makes it Easier for Drugs to Enter the Inner Ear"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1000-1894","authenticated-orcid":false,"given":"Yujie","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-9971","authenticated-orcid":false,"given":"Tongxiang","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2561-3394","authenticated-orcid":false,"given":"Lisheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.WHO Report on Hearing. 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