{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:28:29Z","timestamp":1783452509893,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The EuroQol 5\u2010Dimension (EQ\u20105D) is a general health survey that is quick to administer, widely used, and directly convertible to health utility values (HUV). We aim to describe the five\u2010year EQ\u20105D outcomes among patients who undergo surgical treatment for chronic rhinosinusitis (CRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with CRS completed the EQ\u20105D questionnaire preoperatively and annually for five years following endoscopic sinus surgery. Paired t\u2010tests and McNemar's tests were used to compare preoperative and postoperative scores. Mixed\u2010effects modeling was used for multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1296 patients enrolled in our study, 812 (74.7%) completed the postoperative survey at one year and 336 (38.9%) completed it at five years. There was a significant and sustained reduction of patients reporting pain\/discomfort (74.9% vs. 58.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and anxiety\/depression (49.6% vs. 38.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) out to five years. Frequency of problems reported in the usual activity domain decreased at one year and was sustained through year four (30.6% vs 19.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). After multivariable modeling, female gender (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), prior sinus surgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), tobacco use (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), headaches (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), allergies (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), diabetes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), hypertension (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036), higher preoperative SNOT\u201022 score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and a lower preoperative Lund\u2010Mackay score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were associated with significantly worse EQ\u20105D HUV over time. Similarly, a worse EQ\u20105D Visual Analog Scale (VAS) over time was associated with allergies (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), diabetes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), hypertension (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), higher preoperative SNOT\u201022 score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and prior sinus surgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with chronic rhinosinusitis experience significant sustained improvements in health\u2010related quality of life up to five years after ESS as measured by the EQ\u20105D instrument.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      Level 2\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 134:2592\u20132601, 2024\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.31206","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T07:30:40Z","timestamp":1703143840000},"page":"2592-2601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Five\u2010year\n                    <scp>EuroQol 5\u2010Dimension<\/scp>\n                    Outcomes After Endoscopic Sinus Surgery"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8938-1983","authenticated-orcid":false,"given":"Katherine","family":"Tashman","sequence":"first","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts U.S.A."},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4457-0887","authenticated-orcid":false,"given":"Dara","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thad W.","family":"Vickery","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric H.","family":"Holbrook","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey T.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0783-8861","authenticated-orcid":false,"given":"Benjamin S.","family":"Bleier","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Scangas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Metson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989570152-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21057"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21847"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.03.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-017-0310-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.675523"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X132622"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24715"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25054"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814529536"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22886"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21282"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.11.044"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.4730020307"},{"issue":"2","key":"e_1_2_6_18_1","first-page":"110","article-title":"Responsiveness and minimal clinically important difference for the EQ\u20105D in chronic rhinosinusitis","volume":"57","author":"Hoehle LP","year":"2019","journal-title":"Rhinology"},{"key":"e_1_2_6_19_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0301-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2020.1754189"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000182825.82910.80"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.009"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0175-2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.4103"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2196\/10178"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21539"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7596-1_3"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29405"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21664"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31804b1a90"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino16.211"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21667"},{"key":"e_1_2_6_34_1","article-title":"Sex differences in presentation and surgical outcomes from a prospective multicenter chronic Rhinosinusitis study","author":"Asokan A","year":"2022","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-47622-9"},{"issue":"6","key":"e_1_2_6_36_1","first-page":"545","article-title":"Patient\u2010reported chronic rhinosinusitis disease control is a valid measure of disease burden","volume":"59","author":"Phillips KM","year":"2021","journal-title":"Rhinology"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.4354"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24592"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22109"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1999.00199.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.06.033"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.004"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.31206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T01:42:17Z","timestamp":1771378937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,21]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/lary.31206"],"URL":"https:\/\/doi.org\/10.1002\/lary.31206","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,21]]},"assertion":[{"value":"2023-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}