{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T10:54:06Z","timestamp":1771844046539,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Squamous cell carcinoma of the nasal vestibule (NV\u2010SCC) is a rare but challenging entity, due to the complex anatomy of the region. Consensus on the best treatment strategy is still lacking, as well as a dedicated staging system. Our aim was to analyze oncological outcomes of surgically treated patients and to investigate possible prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective multi\u2010centric observational study including six Academic Hospitals over a 10\u2010year period, including only patients who underwent upfront surgery for primary NV\u2010SCC. Patients were staged according to all currently available staging systems. The Kaplan\u2013Meier method was used to compute overall, disease\u2010free, and disease\u2010specific survival. Logistic regression models were used to correlate between survival outcomes and clinical and pathological variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010one patients with a median follow\u2010up of 38\u2009months were included in the study. Partial and total rhinectomy were the most commonly performed procedures, respectively, in 49.3% and 25.4% of cases. Neck dissection was performed on 31% of patients, and 45.1% of them underwent adjuvant radiotherapy. Three years overall, disease\u2010specific and disease\u2010free survival were, respectively, 86.5%, 90.3%, and 74.2%. None of the currently available staging systems were able to effectively stratify survival outcomes. Factors predicting lower overall survival on multivariate analysis were age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021) and perineural invasion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.059), whereas disease\u2010free survival was negatively affected by age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033) and lymphovascular invasion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Currently available staging systems cannot stratify prognosis for patients who underwent surgery for NV\u2010SCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 134:2634\u20132645, 2024\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.31251","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T23:23:55Z","timestamp":1703892235000},"page":"2634-2645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Squamous Cell Carcinoma of the Nasal Vestibule: A Multi\u2010Centric Observational Cohort Study"],"prefix":"10.1002","volume":"134","author":[{"given":"Francesca","family":"Pirola","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-3850","authenticated-orcid":false,"given":"Davide","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Candiolo Cancer Institute, FPO\u2010IRCCS  Candiolo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-9088","authenticated-orcid":false,"given":"Mario","family":"Turri\u2010Zanoni","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"},{"name":"Head and Neck Surgery &amp; Forensic Dissection Research center (HNS&amp;FDRc), Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-2846","authenticated-orcid":false,"given":"Emilien","family":"Chabrillac","sequence":"additional","affiliation":[{"name":"Department of Surgery University Cancer Institute Toulouse\u2010Oncopole  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-2060","authenticated-orcid":false,"given":"Dario","family":"Fradeani","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Surgery, Sheffield Teaching Hospitals Foundation Trust Royal Hallamshire Hospital  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Sionis","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Surgery, Sheffield Teaching Hospitals Foundation Trust Royal Hallamshire Hospital  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Carta","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero\u2010Universitaria di Cagliari University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2956-5895","authenticated-orcid":false,"given":"Alessia","family":"Lambertoni","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"},{"name":"Head and Neck Surgery &amp; Forensic Dissection Research center (HNS&amp;FDRc), Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Malvezzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-8091","authenticated-orcid":false,"given":"Andrea","family":"Galli","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale San Raffaele; Department of Otolaryngology\u2010Head and Neck Surgery San Raffaele Scientific Institute, Vita\u2010Salute University  Milan Italy"},{"name":"Universit\u00e0 Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-4205","authenticated-orcid":false,"given":"Leone","family":"Giordano","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale San Raffaele; Department of Otolaryngology\u2010Head and Neck Surgery San Raffaele Scientific Institute, Vita\u2010Salute University  Milan Italy"},{"name":"Universit\u00e0 Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2829-0583","authenticated-orcid":false,"given":"Roberto","family":"Puxeddu","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero\u2010Universitaria di Cagliari University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5184-6140","authenticated-orcid":false,"given":"Paolo","family":"Castelnuovo","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"},{"name":"Head and Neck Surgery &amp; Forensic Dissection Research center (HNS&amp;FDRc), Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Mercante","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Spriano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ferreli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Otorhinolaryngology Unit IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2007.01353.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23549"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108002259"},{"issue":"1","key":"e_1_2_7_5_1","first-page":"33","article-title":"Squamous cell carcinoma of the nasal vestibule and anterior nasal passages","volume":"15","author":"Pantelakos ST","year":"1994","journal-title":"Am J Otolaryngol\u2013Head Neck Med Surg"},{"issue":"2","key":"e_1_2_7_6_1","first-page":"189","article-title":"Squamous cell carcinoma of the nasal vestibule treatment results","volume":"23","author":"Johansen LV","year":"1984","journal-title":"Acta Oncol (Madr)"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2020.03.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2660-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29107"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25498"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869609098525"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2019.3599"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31815aff1f"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197607)38:1<100::AID-CNCR2820380118>3.0.CO;2-9"},{"key":"e_1_2_7_15_1","volume-title":"AJCC Cancer Staging Form Supplement","year":"2017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.107450"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21132"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2021.1994646"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.105880"},{"key":"e_1_2_7_20_1","first-page":"117","article-title":"Squamous cell carcinoma of the nasal vestibule","volume":"37","author":"Horsmans JDJ","year":"1999","journal-title":"Rhinology"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10023"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06972-6"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21570"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3603-z"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.8.796"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.31251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T01:42:08Z","timestamp":1771378928000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,29]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/lary.31251"],"URL":"https:\/\/doi.org\/10.1002\/lary.31251","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,29]]},"assertion":[{"value":"2023-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}