{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:15:10Z","timestamp":1780424110216,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:00:00Z","timestamp":1704499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify distinct clinical subtypes of M\u00e9ni\u00e8re's disease by analyzing data acquired from a UK registry of patients who have been diagnosed with M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with M\u00e9ni\u00e8re's disease were identified at secondary\/tertiary care clinics. Cluster analysis was performed by grouping participants sharing similar characteristics and risk factors into groups based on a defined measure of similarity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 411 participants were recruited into this study. Two main clusters were identified: participants diagnosed with ear infections (OR\u2009=\u20090.30, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.014, 95% CI: 0.11\u20130.78) were more likely to be allocated in Cluster 1 (C1). Participants reporting tinnitus in both ears (OR\u2009=\u200911.89, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, 95% CI: 4.08\u201334.64), low pitched tinnitus (OR\u2009=\u200921.09, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, 95% CI: 7.47\u201359.54), and those reporting stress as a trigger for vertigo attacks (OR\u2009=\u200914.94, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, 95% CI: 4.54\u201349.10) were significantly more likely to be in Cluster 2 (C2). Also, participants diagnosed with Benign Paroxysmal Positional Vertigo (OR\u2009=\u200913.14, &lt;0.001, 95% CI: 4.35\u201339.74), autoimmune disease (OR\u2009=\u20095.97, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.007, 95% CI: 1.62\u201322.03), depression (OR\u2009=\u20094.72, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.056, 95% CI: 0.96\u201323.24), migraines (OR\u2009=\u20093.13, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.008, 95% CI: 1.34\u20137.26), drug allergy (OR\u2009=\u20093.25, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.029, 95% CI: 1.13\u20139.34), and hay fever (OR\u2009=\u20093.12, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.009, 95% CI: 1.33\u20137.34) were significantly more likely to be clustered in C2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study supports the hypothesis that M\u00e9ni\u00e8re's disease is a heterogeneous condition with subgroups that may be identifiable by clinical features. Two main clusters were identified with differing putative etiological factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 134:3286\u20133292, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31272","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T11:58:35Z","timestamp":1704542315000},"page":"3286-3292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cluster Analysis to Identify Clinical Subtypes of M\u00e9ni\u00e8re's Disease"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-6283","authenticated-orcid":false,"given":"John","family":"Phillips","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Norfolk and Norwich University Hospitals NHS Foundation Trust  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Murdin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Guy's and St. Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizanur","family":"Khondoker","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Grant","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Shepstone","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Sims","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rea","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University Hospitals of Leicester NHS Trust  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonny","family":"Harcourt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000264"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200111000-00030"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000041"},{"key":"e_1_2_6_5_1","unstructured":"James Lind Alliance \u2013 Priority Setting Partnership.2023.http:\/\/www.jla.nihr.ac.uk\/priority\u2010setting\u2010partnerships\/ear\u2010nose\u2010and\u2010throat\u2010aspects\u2010of\u2010balance\/top\u201010\u2010priorities\/"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7930-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818773077"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181f6c8d2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12844"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00182"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1114866"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.227"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1109\/MIS.2015.60"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","unstructured":"SchulamP WigleyF SariaS.Clustering longitudinal clinical marker trajectories from electronic health data: applications to phenotyping and endotype discovery. 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