{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:34:16Z","timestamp":1772120056299,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M723557"],"award-info":[{"award-number":["2022M723557"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974424"],"award-info":[{"award-number":["81974424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073009"],"award-info":[{"award-number":["82073009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173341"],"award-info":[{"award-number":["82173341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The existing epidemiological evidence regarding the intricate relationship between allergic diseases and chronic adenotonsillar diseases (CATD) remains inconclusive. Herein, the objective of our study is to explore the causal association using Mendelian randomization (MR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Employing data from large genome\u2010wide association studies, a comprehensive two\u2010sample bidirectional MR study was conducted. The studied traits encompassed allergic rhinitis (cases\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099707, controls\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009331173), allergic asthma (cases\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098525, controls\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009193857), allergic conjunctivitis (cases\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918321, controls\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009324178), atopic dermatitis (cases\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911964, controls\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009306909), and CATD (cases\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938983, controls\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009258553). All the patients were of European descent and participants in cohort studies. The primary analysis was executed using inverse\u2010variance\u2010weighted MR. Furthermore, six additional MR methods (MR\u2010Egger, weighted median, simple mode, weighted mode, MR pleiotropy residual sum and outlier, MR robust adjusted profile score) were employed to ensure the reliability and detect potential horizontal pleiotropy within the results. The estimates obtained from the MR analysis were factored into the overall effect calculation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Genetically anticipated outcomes demonstrated a significant association between CATD risk and allergic rhinitis (OR\u2009=\u20091.141,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20096.30E\u221206), allergic asthma (OR\u2009=\u20091.115,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20098.31E\u221205), allergic conjunctivitis (OR\u2009=\u20091.197,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20098.69E\u221207), and a suggestive association with atopic dermatitis (OR\u2009=\u20091.053,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040). However, no substantial correlation was observed in the reverse direction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings of our study provide evidence supporting a causal role of allergic diseases in the development of CATD, whereas the converse relationship does not appear to hold true.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      3\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 134:2653\u20132658, 2024\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.31275","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T08:27:55Z","timestamp":1704788875000},"page":"2653-2658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Allergic Diseases and Chronic Adenotonsillar Diseases: A Mendelian Randomization Study"],"prefix":"10.1002","volume":"134","author":[{"given":"Huihong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Xiangya Hospital Central South University  Changsha People's Republic of China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha People's Republic of China"},{"name":"Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province  Changsha People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-3816","authenticated-orcid":false,"given":"Gangcai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, The Second Xiangya Hospital Central South University  Changsha People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5102-0309","authenticated-orcid":false,"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Xiangya Hospital Central South University  Changsha People's Republic of China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha People's Republic of China"},{"name":"Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province  Changsha People's Republic of China"},{"name":"National Clinical Research Center for Geriatric Disorders (Xiangya Hospital)  Changsha People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2251-7188","authenticated-orcid":false,"given":"Donghai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Xiangya Hospital Central South University  Changsha People's Republic of China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha People's Republic of China"},{"name":"Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province  Changsha People's Republic of China"},{"name":"National Clinical Research Center for Geriatric Disorders (Xiangya Hospital)  Changsha People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Xiangya Hospital Central South University  Changsha People's Republic of China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha People's Republic of China"},{"name":"Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province  Changsha People's Republic of China"},{"name":"National Clinical Research Center for Geriatric Disorders (Xiangya Hospital)  Changsha People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-8349","authenticated-orcid":false,"given":"Li","family":"She","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Xiangya Hospital Central South University  Changsha People's Republic of China"},{"name":"Otolaryngology Major Disease Research Key Laboratory of Hunan Province  Changsha People's Republic of China"},{"name":"Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province  Changsha People's Republic of China"},{"name":"National Clinical Research Center for Geriatric Disorders (Xiangya Hospital)  Changsha People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/187221312800166877"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)60734\u20105"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.23812\/21\u20101supp2\u20107"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392\u2010100X\u2010N1225"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjx005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25441"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj\u20102018\u2010135602"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223\u2010022\u201000732\u20109"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2021.110799"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.09.016"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.2008.080196"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2022.12.017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201014389\u20108"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14682"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100099\u20107"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","unstructured":"ZhaoQ WangJ HemaniG BowdenJ SmallDS.Statistical inference in two\u2010sample summary\u2010data Mendelian randomization using robust adjusted profile score.2019.","DOI":"10.1101\/769562"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac011"},{"issue":"5","key":"e_1_2_7_19_1","first-page":"322","article-title":"Frequency of adenoid hypertrophy in children with allergic diseases","volume":"60","author":"Modrzy\u0144ski M","year":"2003","journal-title":"Przegl Lek"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2011.01.026"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","unstructured":"ZhangX SunB LiS JinH ZhongN ZengG.Local atopy is more relevant than serum sIgE in reflecting allergy in childhood adenotonsillar hypertrophy\u2014Zhang\u20142013\u2014Pediatric Allergy and Immunology\u2014Wiley Online Library.1970. Accessed July 30 2023.https:\/\/doi.org\/10.1111\/pai.12089.","DOI":"10.1111\/pai.12089"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15458"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12235"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880260022005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","unstructured":"AmeliF BrocchettiF ToscaMA SchiavettiI CiprandiG.Tonsil Volume and Allergic Rhinitis in Children \u2010 Franco Ameli Fabio Brocchetti Maria Angela Tosca Irene Schiavetti Giorgio Ciprandi 2014.1970. Accessed July 30 2023https:\/\/doi.org\/10.2500\/ar.2014.5.0095.","DOI":"10.2500\/ar.2014.5.0095"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino14.013"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.5935\/1808\u20108694.20130123"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.855185"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46615"},{"issue":"5","key":"e_1_2_7_30_1","first-page":"317","article-title":"Histopathological and immunological analysis of hyperplastic palatine tonsils and adenoids in children with coexisting atopic dermatitis","volume":"60","author":"Modrzy\u0144ski M","year":"2003","journal-title":"Przegl Lek"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.31275","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T01:41:08Z","timestamp":1771378868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,9]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/lary.31275"],"URL":"https:\/\/doi.org\/10.1002\/lary.31275","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,9]]},"assertion":[{"value":"2023-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}