{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:36:21Z","timestamp":1783697781733,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to describe the overall survival (OS) and to identify associated prognostic factors in patients with inoperable and metastatic cutaneous melanoma of the head and neck (H&amp;N) region, undergoing modern systemic treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective single institutional study. Data on all consecutive H&amp;N melanoma patients treated with systemic oncologic treatments between 2015 and 2022 were collected from electronic medical files. Kaplan\u2013Meier curves were used to describe survival and Cox regression analysis was used to identify patient and tumor factors associated with prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 144 patients were included. Median OS was 45\u2009months (95% confidence interval [CI] 28\u201365\u2009m). On univariable analysis for OS, the primary disease site, specifically the nape and neck (hazard ratio [HR] 3.3, 95% CI 1.4\u20137.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), high Eastern Cooperative Oncology Group Performance Status ([ECOG\u2010PS], HR 2.5, 95% CI\u2009=\u20091.9\u20133.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), high lactate dehydrogenase (LDH) levels (HR 2.8, 95% CI\u2009=\u20091.7\u20134.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and treatment with targeted therapy (TT) as compared with immunotherapy (HR 2.6, 95% CI\u2009=\u20091.06\u20136.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) were all associated with shorter OS. High\u2010grade adverse events (AEs) were associated with a longer OS (HR 0.41, 95% CI\u2009=\u20090.25\u20130.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). On multivariable analysis for OS, the ECOG\u2010PS, LDH levels, site of disease, and the development of moderate\u2010severe AEs remained significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the era of modern oncologic treatments, the prognosis of inoperable and metastatic cutaneous H&amp;N melanoma aligns with other cutaneous melanomas. Primary tumor site of the nape and neck region emerges as a significant prognostic factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      3\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 134:2762\u20132770, 2024\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.31290","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T09:03:32Z","timestamp":1705482212000},"page":"2762-2770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010World Outcomes of Inoperable and Metastatic Cutaneous Head and Neck Melanoma Patients"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-2533","authenticated-orcid":false,"given":"Noa","family":"Rozendorn","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Sheba Medica Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itay","family":"Shutan","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilad","family":"Feinmesser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Sheba Medica Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirly","family":"Grynberg","sequence":"additional","affiliation":[{"name":"Ella Lemelbaum Institute of Immuno\u2010Oncology, Sheba Medical Center  Ramat Gan 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