{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:05:48Z","timestamp":1788606348026,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oral lichen planus (OLP) is a chronic inflammatory disorder involving epithelia with squamous differentiation. Although described as a potential malignant precursor, the characteristics of malignancies arising among these patients are not widely described. Our goal was to describe the patterns of disease recurrence of patients with oral cavity squamous cell carcinoma (OSCC) arising on the background of OLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of all surgically treated patients with OSCC at a university\u2010affiliated tertiary care center between 2000 and 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred seventy\u2010nine patients with OSCC treated surgically were included. Forty (14.3%) had OLP. The mean age of patients with OLP was 70.9\u2009years compared with 64.3\u2009years for non\u2010OLP patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). OLP patients had a significantly higher rate of disease recurrence, persistence, or multiple primary disease (70% vs. 33.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The mean number of sequential oncologic events for each patient with recurrence was also significantly higher among OLP patients (1.86 vs. 1.36, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), a difference explained by a higher rate of multiple primary presentations (0.71 vs. 0.28, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). A significant difference in disease\u2010free survival (DFS) was demonstrated between the groups as patients with OLP had a lower 5\u2010year DFS (34.7% vs. 61.3%, log\u2010rank <jats:italic>p<\/jats:italic> value &lt;0.001). On multivariate analysis, OLP was significantly associated with multiple primary events (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, Odds ratio\u2009=\u20097.42, 95% confidence interval 2.9\u201319).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OSCC patients with OLP background demand close clinical follow\u2010up, as multiple primary disease is significantly more common and the DFS is significantly lower among these patients. A thorough clinical evaluation for all oral cavity subsites is mandatory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 134:3146\u20133151, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31307","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T10:53:45Z","timestamp":1706093625000},"page":"3146-3151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Clinical Behavior and Recurrence Patterns of Oral Cavity Cancer in Oral Lichen Planus Patients"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-9774","authenticated-orcid":false,"given":"Eyal","family":"Yosefof","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Rabin Medical Center  Petah Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv 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