{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:08:16Z","timestamp":1788959296277,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Renal impairment and some systemic diseases are associated with hearing loss (HL) in adults. However, studies of these relationship in adolescents are rare. The objective of this study was to determine the association between HL and renal or systemic disease in adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were extracted from the 5th Korea National Health and Nutrition Examination Survey from 2011 to 2012. We included adolescents aged 10\u201319\u2009years old with normal tympanic membrane and those who underwent a physical and laboratory examination and pure tone audiometry. HL, high\u2010frequency hearing loss (HFHL), albuminuria, impaired glomerular filtration rate, hypertension, diabetes, and obesity were evaluated based on the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with microalbuminruia (MIA) exhibited higher prevalence of HL (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and HFHL (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) than those without MIA. The prevalence of HL and HFHL appeared to increase according to the severity of albuminuria. Additionally, individuals with HL or HFHL showed lower transferrin saturation (TSAT) than individuals without HL (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) or HFHL (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). And, HFHL was associated with lower ferritin levels (<jats:italic>p<\/jats:italic>\u2009=\u20090.017). HL and HFHL were related to MIA (<jats:italic>p<\/jats:italic>\u2009=\u20090.004 and <jats:italic>p<\/jats:italic>\u2009=\u20090.022, respectively) and TSAT (<jats:italic>p<\/jats:italic>\u2009=\u20090.005 and <jats:italic>p<\/jats:italic>\u2009=\u20090.011, respectively) after controlling other factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MIA and TSAT level were independently associated with the HL and HFHL. Since MIA can be easily detected by dipstick test and urine analysis, hearing evaluations for individuals with MIA might be helpful to identify hearing impairments earlier in adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 (individual cross\u2010sectional study) <jats:italic>Laryngoscope<\/jats:italic>, 134:3329\u20133334, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31317","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:27:02Z","timestamp":1707294422000},"page":"3329-3334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microalbuminuria and Functional Iron Deficiency are Risk Factors for Hearing Loss in Adolescents"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-8531","authenticated-orcid":false,"given":"Sang\u2010Yoon","family":"Han","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7328-5068","authenticated-orcid":false,"given":"Young Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1616601"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2022.01557"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17647"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.14293"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14101231"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2016.00787"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2020.35.e364"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2017.04.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99792-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-01810-z"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1044\/2017_AJA-16-0093"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.75"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.11.014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819868145"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101423"},{"key":"e_1_2_7_17_1","first-page":"179","article-title":"Evaluation of hearing loss in juvenile insulin dependent patients with diabetes mellitus","volume":"16","author":"Okhovat SA","year":"2011","journal-title":"J Res Med Sci"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.03.020"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000226286.19295.34"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24244"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1739312"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.10.003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.5.556"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(01)00224-6"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.11.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2013.79"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220802595948"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AUD.0000069226.22983.80"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.14.1071"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000802"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.04.029"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-015-0789-x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4691-2"},{"key":"e_1_2_7_34_1","unstructured":"World Health Organization.Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. 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