{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:49:37Z","timestamp":1779392977803,"version":"3.53.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We undertook a systematic review of the literature with meta\u2010analysis to identify the role of obesity (BMI \u226530) in the patient characteristics presenting with spontaneous cerebrospinal fluid (sCSF) leaks of the lateral skull base and the outcomes of their repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>A Systematic Review of English Articles using MEDLINE, EMBASE, and Cochrane Library.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>The research algorithm included the following keywords: \u201cspontaneous CSF leak,\u201d \u201clateral skull base,\u201d \u201ctemporal bone,\u201d \u201cmeningocele,\u201d \u201cencephalocele,\u201d and \u201cotorrhea.\u201d We also manually searched the references of included studies, to identify possible studies missed during our literature search.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More than two\u2010thirds of the patients were female (69.2%) and often were obese (mean BMI 36.5\u2009kg\/m<jats:sup>2<\/jats:sup>) with a mean age of 57. Most common presenting symptoms were otorrhea and hearing loss. Most authors did not report a routine use of a post\u2010operative lumbar drain. Most patients had a single skull base defect and encephaloceles prolapsing through, across obese and non\u2010obese groups. Median length of stay in hospital was 3.2\u2009days, and the majority of patients did not have any recurrence during their follow\u2010up (89.6%), which was not affected by obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obesity does not affect length of hospital stay or recurrence rate following surgical repair of lateral skull base sCSF leaks. Surgical repair is a safe and viable approach in the management of obese patients with sCSF leaks in the temporal bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 134:2012\u20132018, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31349","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T14:04:55Z","timestamp":1708783495000},"page":"2012-2018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Association Between Obesity and Spontaneous Temporal Bone CSF Leak Outcomes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6171-2947","authenticated-orcid":false,"given":"Dimitrios","family":"Spinos","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery South Warwickshire University NHS Foundation Trust  Warwick UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Geropoulos","sequence":"additional","affiliation":[{"name":"Department of Surgery Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Vavoulis","sequence":"additional","affiliation":[{"name":"Society of Junior Doctors Surgical Working Group  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Georgountzos","sequence":"additional","affiliation":[{"name":"Society of Junior Doctors Surgical Working Group  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manthia","family":"Papageorgakopoulou","sequence":"additional","affiliation":[{"name":"Society of Junior Doctors Surgical Working Group  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina Rafailia","family":"Karela","sequence":"additional","affiliation":[{"name":"Society of Junior Doctors Surgical Working Group  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Varoutis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery General Hospital of Thessaloniki Ippokratio  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriacos","family":"Evangelou","sequence":"additional","affiliation":[{"name":"Society of Junior Doctors Surgical Working Group  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Sum","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8740352"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.09.114"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318268d350"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.4.Focus1265"},{"issue":"2","key":"e_1_2_6_6_1","first-page":"97","article-title":"Transmastoid approach to repair meningoencephalic herniation in the middle ear","volume":"33","author":"Sergi B","year":"2013","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12901-017-0044-x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2015.06.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.Neu.0000298903.63635.E3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073274819853831"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2012.01621.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opab276"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_6_14_1","unstructured":"Study Quality Assessment Tools National Heart Lung and Blood Institute.2021https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_6_17_1","unstructured":"HigginsJPTTJ ChandlerJ CumpstonM LiT PageMJ WelchVA eds.Cochrane Handbook for Systematic Reviews of Interventions Version 6.4. 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