{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:05:22Z","timestamp":1788829522371,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The prognostic value of depth of invasion (DOI) in oral squamous cell cancer carcinoma and cutaneous melanoma is well established, while there is a lack of reports investigating the role of DOI in laryngeal cancer. This study aims to explore the association of glottic cancer DOI with other established pathological risk factors and nodal metastasis and evaluate the feasibility of measuring DOI preoperatively using tomographic imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of glottic cancer patients treated between 2015 and 2020 in a single tertiary referral center were screened retrospectively. Pathologically measured DOI (pDOI) value was also reviewed and registered. Preoperative computer tomography (CT) was used to obtain the radiological DOI (rDOI) measured by two dedicated radiologists. Their inter\u2010rated agreement was assessed and the correlation between pDOI and rDOI was calculated. pDOI association with the main pathology report features was assessed with univariable analysis. Cox univariable and multivariable models were used to explore the role of pDOI on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010one patients had pDOI data available, of which 59 also had rDOI data. A strong concordance between the two radiologists was found (concordance correlation coefficient\u2009=\u20090.96); rDOI and pDOI were highly and significantly correlated (<jats:italic>R<\/jats:italic>\u2009=\u20090.85; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). pDOI was significantly higher in patients with perineural invasion (PNI; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), lymphovascular invasion (LVI; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and nodal metastasis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). pDOI was associated with disease\u2010free survival at univariable analysis (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) while it did not show a significant impact (<jats:italic>p<\/jats:italic>\u2009=\u20090.10) at multivariable analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Glottic carcinoma DOI correlates with PNI, LVI, and nodal metastasis and it can be reliably assessed in a preoperative setting using CT imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 134:3230\u20133237, 2024<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.31369","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T13:53:40Z","timestamp":1708955620000},"page":"3230-3237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Depth of Invasion Assessment in Laryngeal Glottic Carcinoma: A Preoperative Imaging Approach for Prognostication"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6000-3006","authenticated-orcid":false,"given":"Marta","family":"Filauro","sequence":"first","affiliation":[{"name":"Unit of Otolaryngology Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Caprioli","sequence":"additional","affiliation":[{"name":"Unit of Oncological and Interventional Radiology IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Internal Medicine (DIMI) University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Lovino Camerino","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"},{"name":"Department of Otorhinolaryngology Ospedale S. Paolo  Savona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-2291","authenticated-orcid":false,"given":"Claudio","family":"Sampieri","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine (DIMES) University of Genova  Genoa Italy"},{"name":"Otorhinolaryngology Department Hospital Cl\u00ednic  Barcelona Spain"},{"name":"Functional Unit of Head and Neck Tumors Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Conforti","sequence":"additional","affiliation":[{"name":"Unit of Oncological and Interventional Radiology IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-3045","authenticated-orcid":false,"given":"Andrea","family":"Iandelli","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Benzi","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Gabella","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"bellini","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mora","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cittadini","sequence":"additional","affiliation":[{"name":"Unit of Oncological and Interventional Radiology IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Peretti","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Marchi","sequence":"additional","affiliation":[{"name":"Unit of Otolaryngology Head and Neck Surgery IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC) University of Genova  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0B013E31829D7F35"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1986.01400120060009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_6_5_1","unstructured":"HaddadRI HicksWL HitchcockYJ et al.NCCN Guidelines Version 1.2023 Head and Neck Cancers Continue NCCN Guidelines Panel Disclosures.2022.https:\/\/www.nccn.org\/home\/member."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192214900"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06421-w"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01571"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/CANCERS12082241"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199805000-00025"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00405-017-4793-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/HED.25667"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2022.12.006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195769"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26861"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3024-4"},{"key":"e_1_2_6_17_1","unstructured":"AndaloroC WidrichJ.Total laryngectomy.2023."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0016"},{"issue":"3","key":"e_1_2_6_19_1","first-page":"705","article-title":"The histogenesis and biologic behavior of primary human malignant melanomas of the skin","volume":"29","author":"Clark WHJ","year":"1969","journal-title":"Cancer Res"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109137418"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1219-5"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2023.2169040"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-5586-7"},{"issue":"7","key":"e_1_2_6_24_1","first-page":"873","article-title":"Head and Neck Cancers, NCCN clinical practice guidelines in oncology (NCCN guidelines\u00ae)","volume":"18","author":"Bruce JY","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000240"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24534"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.07.008"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/HED.20502"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988609500215"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4642-4"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050717"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00175"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28323"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000234917.08822.cd"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.31369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T10:00:31Z","timestamp":1718618431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.31369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/lary.31369"],"URL":"https:\/\/doi.org\/10.1002\/lary.31369","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,26]]},"assertion":[{"value":"2023-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}